Biomimetic remineralization of resin-bonded acid-etched dentin

F. R. Tay, D. H. Pashley

Research output: Contribution to journalArticlepeer-review

133 Scopus citations


Degradation of denuded collagen within adhesive resin-infiltrated dentin is a pertinent problem in dentin bonding. A biomimetic remineralization scheme that incorporates non-classic crystallization pathways of fluidic amorphous nanoprecursors and mesoscopic transformation has been successful in remineralizing resin-free, acid-etched dentin, with evidence of intrafibrillar and interfibrillar remineralization. This study tested the hypothesis that biomimetic remineralization provides a means for remineralizing incompletely infiltrated resin-dentin interfaces created by etch-and-rinse adhesives. The remineralization medium consists of a Portland cement/simulated body fluid that includes polyacrylic acid and polyvinylphosphonic acid biomimetic analogs for amorphous calcium phosphate dimension regulation and collagen targeting. Both interfibrillar and intrafibrillar apatites became readily discernible within the hybrid layers after 2-4 months. In addition, intra-resin apatite clusters were deposited within the porosities of the adhesive resin matrices. The biomimetic remineralization scheme provides a proof-of-concept for the adoption of nanotechnology as an alternative strategy to extend the longevity of resin-dentin bonds.

Original languageEnglish (US)
Pages (from-to)719-724
Number of pages6
JournalJournal of Dental Research
Issue number8
StatePublished - Aug 2009


  • Biomimetics
  • Biomineralization
  • Degradation
  • Dentin bonding agent
  • Intrafibrillar
  • Nanocomposite.
  • Remineralization

ASJC Scopus subject areas

  • Dentistry(all)


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