Biomolecular characterization and protein sequences of the campanian hadrosaur b. canadensis

Mary H. Schweitzer, Wenxia Zheng, Chris L. Organ, Recep Avci, Zhiyong Suo, Lisa M. Freimark, Valerie S. Lebleu, Michael B. Duncan, Matthew G.Vander Heiden, John M. Neveu, William S. Lane, John S. Cottrell, John R. Horner, Lewis C. Cantley, Raghu Kalluri, John M. Asara

Research output: Contribution to journalArticlepeer-review

173 Scopus citations

Abstract

Molecular preservation in non-avian dinosaurs is controversial. We present multiple lines of evidence that endogenous proteinaceous material is preserved in bone fragments and soft tissues from an 80-million-year-old Campanian hadrosaur, Brachylophosaurus canadensis [Museum of the Rockies (MOR) 2598]. Microstructural and immunological data are consistent with preservation of multiple bone matrix and vessel proteins, and phylogenetic analyses of Brachylophosaurus collagen sequenced by mass spectrometry robustly support the bird-dinosaur clade, consistent with an endogenous source for these collagen peptides. These data complement earlier results from Tyrannosaurus rex (MOR 1125) and confirm that molecular preservation in Cretaceous dinosaurs is not a unique event.

Original languageEnglish (US)
Pages (from-to)626-631
Number of pages6
JournalScience
Volume324
Issue number5927
DOIs
StatePublished - May 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • General

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