TY - JOUR
T1 - Blunted rest-activity rhythm is associated with increased white blood-cell-based inflammatory markers in adults
T2 - an analysis from NHANES 2011-2014
AU - Xu, Yanyan
AU - Su, Shaoyong
AU - McCall, William V
AU - Wang, Xiaoling
N1 - Funding Information:
X. W. receives funding from NIH DK117365 and AHA SFRN863620 and S. S. receives funds from NIH HL143440 and MD013307.
Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2022/3/9
Y1 - 2022/3/9
N2 - Circadian rhythm disruption is associated with immune system disturbance and has been observed in many health problems where chronic-inflammation acts as a major contributor. We aim to examine whether rest-activity circadian rhythm is associated with chronic inflammation using white blood-cell-based inflammatory indices including white blood cell (WBC) count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII). We analyzed the data from 8089 adults (age≥20) with at least 4 days of validated accelerometer recordings and a valid WBC count from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Non-parametric rest-activity circadian rhythm parameters were derived from the accelerometer recordings. In the models adjusting multiple covariates, a one-quantile increase in relative amplitude (i.e. more robust circadian rhythm) was associated with 1 × 10
8 cells/L decrease in WBC number (95% CI: 5 × 10
7 to 1.5 × 10
8,
P < .001), 7 × 10
7 cells/L decrease in neutrophils (95% CI: 3 × 10
7 to 1.1 × 10
8,
P = .003) and 15.2 × 10
9 /L decrease in SII (95% CI: 6 × 10
9 /L to 20 × 10
9/L,
P = .019). Consistent results were also observed for the association of M10 value and L5 value with these inflammatory indices. Our results indicated that blunted rest-activity circadian rhythm is associated with increased white blood-cell-based inflammatory indices in adults, suggesting interventions aiming at enhancing circadian rhythm by lifestyle programs may be a novel approach to improve the general health.
AB - Circadian rhythm disruption is associated with immune system disturbance and has been observed in many health problems where chronic-inflammation acts as a major contributor. We aim to examine whether rest-activity circadian rhythm is associated with chronic inflammation using white blood-cell-based inflammatory indices including white blood cell (WBC) count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII). We analyzed the data from 8089 adults (age≥20) with at least 4 days of validated accelerometer recordings and a valid WBC count from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Non-parametric rest-activity circadian rhythm parameters were derived from the accelerometer recordings. In the models adjusting multiple covariates, a one-quantile increase in relative amplitude (i.e. more robust circadian rhythm) was associated with 1 × 10
8 cells/L decrease in WBC number (95% CI: 5 × 10
7 to 1.5 × 10
8,
P < .001), 7 × 10
7 cells/L decrease in neutrophils (95% CI: 3 × 10
7 to 1.1 × 10
8,
P = .003) and 15.2 × 10
9 /L decrease in SII (95% CI: 6 × 10
9 /L to 20 × 10
9/L,
P = .019). Consistent results were also observed for the association of M10 value and L5 value with these inflammatory indices. Our results indicated that blunted rest-activity circadian rhythm is associated with increased white blood-cell-based inflammatory indices in adults, suggesting interventions aiming at enhancing circadian rhythm by lifestyle programs may be a novel approach to improve the general health.
KW - circadian rhythm
KW - inflammation
KW - Rest-activity rhythm
KW - WBC count
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U2 - 10.1080/07420528.2022.2048663
DO - 10.1080/07420528.2022.2048663
M3 - Article
C2 - 35260021
SN - 0742-0528
SP - 1
EP - 8
JO - Chronobiology International
JF - Chronobiology International
ER -