Bone Morphogenetic Proteins: A Realistic Alternative to Bone Grafting for Alveolar Reconstruction

Ulf M E Wikesjö; Yi Hao Huang; Giuseppe Polimeni; Mohammed Qahash

doi:10.1016/j.coms.2007.07.004

Bone Morphogenetic Proteins: A Realistic Alternative to Bone Grafting for Alveolar Reconstruction

Ulf M E Wikesjö
, Yi Hao Huang
, Giuseppe Polimeni
, Mohammed Qahash

Periodontics

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.

Original language	English (US)
Pages (from-to)	535-551
Number of pages	17
Journal	Oral and Maxillofacial Surgery Clinics of North America
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.coms.2007.07.004
State	Published - Nov 2007

ASJC Scopus subject areas

Surgery
Oral Surgery
Otorhinolaryngology

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10.1016/j.coms.2007.07.004

Cite this

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title = "Bone Morphogenetic Proteins: A Realistic Alternative to Bone Grafting for Alveolar Reconstruction",

abstract = "Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.",

author = "Wikesj{\"o}, \{Ulf M E\} and Huang, \{Yi Hao\} and Giuseppe Polimeni and Mohammed Qahash",

note = "Funding Information: Earlier versions of this text have been published for reviews in journals and book chapters. The text is continuously subject to revisions and updating as new information becomes available in our laboratory. The Laboratory for Applied Periodontal \& Craniofacial Regeneration is supported in part by a grant from Nobel Biocare AB, Sweden. ",

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T2 - A Realistic Alternative to Bone Grafting for Alveolar Reconstruction

AU - Wikesjö, Ulf M E

AU - Huang, Yi Hao

AU - Polimeni, Giuseppe

AU - Qahash, Mohammed

N1 - Funding Information: Earlier versions of this text have been published for reviews in journals and book chapters. The text is continuously subject to revisions and updating as new information becomes available in our laboratory. The Laboratory for Applied Periodontal & Craniofacial Regeneration is supported in part by a grant from Nobel Biocare AB, Sweden.

PY - 2007/11

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N2 - Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.

AB - Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.

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DO - 10.1016/j.coms.2007.07.004

M3 - Review article

C2 - 18088904

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JO - Oral and Maxillofacial Surgery Clinics of North America

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ER -

Bone Morphogenetic Proteins: A Realistic Alternative to Bone Grafting for Alveolar Reconstruction

Abstract

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