Bosutinib: A third generation tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia

Brittany G. Hill, Vamsi K. Kota, Hanna Jean Khoury

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Bosutinib is an oral tyrosine kinase inhibitor (TKI) with very potent dual inhibitory activity against SRC and abelson gene. Bosutinib was approved in 2012 for the treatment of resistant Philadelphia chromosome positive chronic myeloid leukemia (CML). Bosutinib is a very effective TKI against all phases of intolerant or resistant CML regardless of the presence or absence of an abelson gene domain mutation, except for cases with detectable T315I or V299L. Bosutinib is overall well tolerated and associated with a unique, but manageable toxicity profile. Factors that influence the prescribing pattern of this drug are complex and include physicians', and increasingly patients and families' preference, patients' comorbid conditions, schedule of administration, as well as financial factors. This paper provides an overview of CML, the TKI market, pharmacokinetics, pharmacodynamics, clinical efficacy, safety and tolerability of bosutinib.

Original languageEnglish (US)
Pages (from-to)765-770
Number of pages6
JournalExpert Review of Anticancer Therapy
Issue number7
StatePublished - Jul 2014


  • Bosutinib
  • Chronic myeloid leukemia
  • Resistant
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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