TY - JOUR
T1 - Brain activation patterns in women with acquired hypoactive sexual desire disorder and women with normal sexual function
T2 - A cross-sectional pilot study
AU - Woodard, Terri L.
AU - Nowak, Nicole T.
AU - Balon, Richard
AU - Tancer, Manuel
AU - Diamond, Michael P.
PY - 2013/10
Y1 - 2013/10
N2 - Objective To examine and compare brain activation patterns of premenopausal women with normal sexual function and those with hypoactive sexual desire disorder (HSDD) during viewing of validated sexually explicit film clips. Design Cross-sectional pilot study. Setting University-based clinical research center. Patient(s) Premenopausal women. Intervention(s) None. Main Outcome Measure(s) Areas of brain activation during viewing of sexually explicit film clips. Result(s) Women with normal sexual function showed significantly greater activation of the right thalamus, left insula, left precentral gyrus, and left parahippocampal gyrus in comparison with women with HSDD, who exhibited greater activation of the right medial frontal gyrus and left precuneus regions. Conclusion(s) Women with HSDD may have alterations in activation of limbic and cortical structures responsible for acquiring, encoding, and retrieving memory, the processing and memory of emotional reactions, and areas responsible for heightened attention to one's own physical state.
AB - Objective To examine and compare brain activation patterns of premenopausal women with normal sexual function and those with hypoactive sexual desire disorder (HSDD) during viewing of validated sexually explicit film clips. Design Cross-sectional pilot study. Setting University-based clinical research center. Patient(s) Premenopausal women. Intervention(s) None. Main Outcome Measure(s) Areas of brain activation during viewing of sexually explicit film clips. Result(s) Women with normal sexual function showed significantly greater activation of the right thalamus, left insula, left precentral gyrus, and left parahippocampal gyrus in comparison with women with HSDD, who exhibited greater activation of the right medial frontal gyrus and left precuneus regions. Conclusion(s) Women with HSDD may have alterations in activation of limbic and cortical structures responsible for acquiring, encoding, and retrieving memory, the processing and memory of emotional reactions, and areas responsible for heightened attention to one's own physical state.
KW - Brain activation patterns
KW - female sexual dysfunction
KW - functional neuroimaging
KW - hypoactive sexual desire disorder (HSDD)
KW - sexual stimuli
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U2 - 10.1016/j.fertnstert.2013.05.041
DO - 10.1016/j.fertnstert.2013.05.041
M3 - Article
C2 - 23830149
AN - SCOPUS:84884904234
SN - 0015-0282
VL - 100
SP - 1068-1076.e5
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 4
ER -