Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

Suling Liu; Christophe Ginestier; Sing J. Ou; Shawn G. Clouthier; Shivani H. Patel; Florence Monville; Hasan Korkaya; Amber Heath; Julie Dutcher; Celina G. Kleer; Younghun Jung; Gabriela Dontu; Russell Taichman; Max S. Wicha

doi:10.1158/0008-5472.CAN-10-0538

Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

Suling Liu, Christophe Ginestier, Sing J. Ou, Shawn G. Clouthier, Shivani H. Patel, Florence Monville, Hasan Korkaya, Amber Heath, Julie Dutcher, Celina G. Kleer, Younghun Jung, Gabriela Dontu, Russell Taichman, Max S. Wicha

Research output: Contribution to journal › Article › peer-review

512 Scopus citations

Abstract

We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow- derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population.

Original language	English (US)
Pages (from-to)	614-624
Number of pages	11
Journal	Cancer Research
Volume	71
Issue number	2
DOIs	https://doi.org/10.1158/0008-5472.CAN-10-0538
State	Published - Jan 15 2011
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/0008-5472.CAN-10-0538

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title = "Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks",

abstract = "We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow- derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population.",

author = "Suling Liu and Christophe Ginestier and Ou, {Sing J.} and Clouthier, {Shawn G.} and Patel, {Shivani H.} and Florence Monville and Hasan Korkaya and Amber Heath and Julie Dutcher and Kleer, {Celina G.} and Younghun Jung and Gabriela Dontu and Russell Taichman and Wicha, {Max S.}",

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doi = "10.1158/0008-5472.CAN-10-0538",

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T1 - Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

AU - Liu, Suling

AU - Ginestier, Christophe

AU - Ou, Sing J.

AU - Clouthier, Shawn G.

AU - Patel, Shivani H.

AU - Monville, Florence

AU - Korkaya, Hasan

AU - Heath, Amber

AU - Dutcher, Julie

AU - Kleer, Celina G.

AU - Jung, Younghun

AU - Dontu, Gabriela

AU - Taichman, Russell

AU - Wicha, Max S.

PY - 2011/1/15

Y1 - 2011/1/15

N2 - We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow- derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population.

AB - We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow- derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population.

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Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

Abstract

ASJC Scopus subject areas

UN SDGs

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