Can Locoregionally Recurrent Breast Cancer Be Cured?

Arati Rani Chand, M. Firdos Ziauddin, Shou Ching Tang

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Locoregional recurrence (LRR) of breast cancer can occur after multidisciplinary treatment of a primary breast cancer. With modern multidisciplinary breast cancer treatment, the incidence of isolated LRR is decreasing. Improvements in systemic therapy are driving the decrease in LRR. LRR does still occur, however. LRR reflects biology of the cancer, as does systemic recurrence. LRR of breast cancer is frequently associated with systemic disease recurrence and poor prognosis. Given this associated poor prognosis, historically, it has been unclear whether patients with LRR would benefit from aggressive therapy with curative intent. Findings in retrospective studies suggest that prognosis for patients with LRR is not universally poor, and some patients may benefit from aggressive locoregional and systemic therapy. The challenge remains to assess prognosis and appropriately treat patients with locoregional breast cancer recurrence.

Original languageEnglish (US)
Pages (from-to)326-335
Number of pages10
JournalClinical Breast Cancer
Issue number5
StatePublished - Aug 2017
Externally publishedYes


  • Locoregional recurrence
  • Prognosis
  • Radiation
  • Surgery
  • Systemic therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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