Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or Β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.
|Original language||English (US)|
|Number of pages||3|
|Journal||Nature Cell Biology|
|State||Published - May 1 2010|
ASJC Scopus subject areas
- Cell Biology