Cancer stem cells: Nature versus nurture

Hasan Korkaya; Max S. Wicha

doi:10.1038/ncb0510-419

Cancer stem cells: Nature versus nurture

Hasan Korkaya, Max S. Wicha

Research output: Contribution to journal › Short survey › peer-review

44 Scopus citations

Abstract

Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or Β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.

Original language	English (US)
Pages (from-to)	419-421
Number of pages	3
Journal	Nature Cell Biology
Volume	12
Issue number	5
DOIs	https://doi.org/10.1038/ncb0510-419
State	Published - May 1 2010
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ncb0510-419

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abstract = "Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or Β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.",

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AB - Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or Β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.

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Cancer stem cells: Nature versus nurture

Abstract

ASJC Scopus subject areas

UN SDGs

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