TY - JOUR
T1 - Candida glabrata
T2 - An important fungal pathogen for the 21st century
AU - Fidel, Paul L.
AU - Vazquez, Jose A.
AU - Sobel, Jack D.
PY - 2001/11/15
Y1 - 2001/11/15
N2 - Although Candida glabrata has been viewed as a relatively nonpathogenic saprophyte, it is now considered an important fungal pathogen. The reason is the widespread use of immunosuppressive therapy, together with broad-spectrum antimycotic therapy to which the organism may be resistant. This article reviews the biology, epidemiology, pathogenesis, clinical spectrum of infection, and antifungal resistance of this yeast. Infections with C. glabrata are likely to increase as antifungal agents continue to be used; therefore, further studies of pathogenesis, host responses, and antifungal resistance mechanisms are needed.
AB - Although Candida glabrata has been viewed as a relatively nonpathogenic saprophyte, it is now considered an important fungal pathogen. The reason is the widespread use of immunosuppressive therapy, together with broad-spectrum antimycotic therapy to which the organism may be resistant. This article reviews the biology, epidemiology, pathogenesis, clinical spectrum of infection, and antifungal resistance of this yeast. Infections with C. glabrata are likely to increase as antifungal agents continue to be used; therefore, further studies of pathogenesis, host responses, and antifungal resistance mechanisms are needed.
UR - http://www.scopus.com/inward/record.url?scp=0035890147&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035890147&partnerID=8YFLogxK
U2 - 10.1016/S0196-4399(01)80058-1
DO - 10.1016/S0196-4399(01)80058-1
M3 - Article
AN - SCOPUS:0035890147
SN - 0196-4399
VL - 23
SP - 171
EP - 176
JO - Clinical Microbiology Newsletter
JF - Clinical Microbiology Newsletter
IS - 22
ER -