TY - JOUR
T1 - Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats
AU - Thounaojam, Menaka C.
AU - Jadeja, Ravirajsinh N.
AU - Ansarullah,
AU - Karn, Sanjay S.
AU - Shah, Jigar D.
AU - Patel, Dipak K.
AU - Salunke, Sunita P.
AU - Padate, Geeta S.
AU - Devkar, Ranjitsinh V.
AU - Ramachandran, A. V.
N1 - Funding Information:
The authors (1, 2, 3 & 6) are grateful to University Grants Commission, New Delhi for providing Financial Assistance in the form of JRFSMS scholarship.
PY - 2011/5
Y1 - 2011/5
N2 - The present study investigates cardioprotective effect of Sida rhomboidea. Roxb (SR) extract on heart weight, plasma lipid profile, plasma marker enzymes, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85mg/kg, s.c.) recorded significant (p<0.05) increment in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation (LPO) and activity levels of Ca+2 ATPase whereas there was significant (p<0.05) decrease in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase. Pre-treatment with SR extract (400mg/kg per day, p.o.) for 30 consecutive days followed by IP injections on days 29th and 30th, showed significant (p<0.05) decrease in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation, Ca+2 ATPase and significant increase in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase compared to IP treated group. Hence, this study is the first scientific report on cardioprotective effect of SR against IP induced MN in rats.
AB - The present study investigates cardioprotective effect of Sida rhomboidea. Roxb (SR) extract on heart weight, plasma lipid profile, plasma marker enzymes, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85mg/kg, s.c.) recorded significant (p<0.05) increment in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation (LPO) and activity levels of Ca+2 ATPase whereas there was significant (p<0.05) decrease in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase. Pre-treatment with SR extract (400mg/kg per day, p.o.) for 30 consecutive days followed by IP injections on days 29th and 30th, showed significant (p<0.05) decrease in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation, Ca+2 ATPase and significant increase in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase compared to IP treated group. Hence, this study is the first scientific report on cardioprotective effect of SR against IP induced MN in rats.
KW - Isoproterenol
KW - Myocardial infarction
KW - Sida rhomboidea. Roxb
UR - http://www.scopus.com/inward/record.url?scp=79953748371&partnerID=8YFLogxK
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U2 - 10.1016/j.etp.2010.02.010
DO - 10.1016/j.etp.2010.02.010
M3 - Article
C2 - 20303721
AN - SCOPUS:79953748371
SN - 0940-2993
VL - 63
SP - 351
EP - 356
JO - Experimentelle Pathologie
JF - Experimentelle Pathologie
IS - 4
ER -