Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats

Menaka C. Thounaojam; Ravirajsinh N. Jadeja; Ansarullah; Sanjay S. Karn; Jigar D. Shah; Dipak K. Patel; Sunita P. Salunke; Geeta S. Padate; Ranjitsinh V. Devkar; A. V. Ramachandran

doi:10.1016/j.etp.2010.02.010

Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats

Menaka C. Thounaojam
, Ravirajsinh N. Jadeja
, Ansarullah
, Sanjay S. Karn
, Jigar D. Shah
, Dipak K. Patel
, Sunita P. Salunke
, Geeta S. Padate
, Ranjitsinh V. Devkar
, A. V. Ramachandran

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The present study investigates cardioprotective effect of Sida rhomboidea. Roxb (SR) extract on heart weight, plasma lipid profile, plasma marker enzymes, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85mg/kg, s.c.) recorded significant (p<0.05) increment in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation (LPO) and activity levels of Ca⁺² ATPase whereas there was significant (p<0.05) decrease in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na⁺-K⁺ ATPase and Mg⁺² ATPase. Pre-treatment with SR extract (400mg/kg per day, p.o.) for 30 consecutive days followed by IP injections on days 29th and 30th, showed significant (p<0.05) decrease in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation, Ca⁺² ATPase and significant increase in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na⁺-K⁺ ATPase and Mg⁺² ATPase compared to IP treated group. Hence, this study is the first scientific report on cardioprotective effect of SR against IP induced MN in rats.

Original language	English (US)
Pages (from-to)	351-356
Number of pages	6
Journal	Experimental and Toxicologic Pathology
Volume	63
Issue number	4
DOIs	https://doi.org/10.1016/j.etp.2010.02.010
State	Published - May 2011
Externally published	Yes

Keywords

Isoproterenol
Myocardial infarction
Sida rhomboidea. Roxb

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Cell Biology

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10.1016/j.etp.2010.02.010

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Thounaojam, M. C., Jadeja, R. N., Ansarullah, Karn, S. S., Shah, J. D., Patel, D. K., Salunke, S. P., Padate, G. S., Devkar, R. V., & Ramachandran, A. V. (2011). Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats. Experimental and Toxicologic Pathology, 63(4), 351-356. https://doi.org/10.1016/j.etp.2010.02.010

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title = "Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats",

abstract = "The present study investigates cardioprotective effect of Sida rhomboidea. Roxb (SR) extract on heart weight, plasma lipid profile, plasma marker enzymes, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85mg/kg, s.c.) recorded significant (p<0.05) increment in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation (LPO) and activity levels of Ca+2 ATPase whereas there was significant (p<0.05) decrease in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase. Pre-treatment with SR extract (400mg/kg per day, p.o.) for 30 consecutive days followed by IP injections on days 29th and 30th, showed significant (p<0.05) decrease in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation, Ca+2 ATPase and significant increase in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase compared to IP treated group. Hence, this study is the first scientific report on cardioprotective effect of SR against IP induced MN in rats.",

keywords = "Isoproterenol, Myocardial infarction, Sida rhomboidea. Roxb",

author = "Thounaojam, \{Menaka C.\} and Jadeja, \{Ravirajsinh N.\} and Ansarullah and Karn, \{Sanjay S.\} and Shah, \{Jigar D.\} and Patel, \{Dipak K.\} and Salunke, \{Sunita P.\} and Padate, \{Geeta S.\} and Devkar, \{Ranjitsinh V.\} and Ramachandran, \{A. V.\}",

note = "Funding Information: The authors (1, 2, 3 \& 6) are grateful to University Grants Commission, New Delhi for providing Financial Assistance in the form of JRFSMS scholarship. ",

year = "2011",

month = may,

doi = "10.1016/j.etp.2010.02.010",

language = "English (US)",

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AU - Thounaojam, Menaka C.

AU - Jadeja, Ravirajsinh N.

AU - Ansarullah,

AU - Karn, Sanjay S.

AU - Shah, Jigar D.

AU - Patel, Dipak K.

AU - Salunke, Sunita P.

AU - Padate, Geeta S.

AU - Devkar, Ranjitsinh V.

AU - Ramachandran, A. V.

N1 - Funding Information: The authors (1, 2, 3 & 6) are grateful to University Grants Commission, New Delhi for providing Financial Assistance in the form of JRFSMS scholarship.

PY - 2011/5

Y1 - 2011/5

N2 - The present study investigates cardioprotective effect of Sida rhomboidea. Roxb (SR) extract on heart weight, plasma lipid profile, plasma marker enzymes, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85mg/kg, s.c.) recorded significant (p<0.05) increment in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation (LPO) and activity levels of Ca+2 ATPase whereas there was significant (p<0.05) decrease in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase. Pre-treatment with SR extract (400mg/kg per day, p.o.) for 30 consecutive days followed by IP injections on days 29th and 30th, showed significant (p<0.05) decrease in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation, Ca+2 ATPase and significant increase in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase compared to IP treated group. Hence, this study is the first scientific report on cardioprotective effect of SR against IP induced MN in rats.

AB - The present study investigates cardioprotective effect of Sida rhomboidea. Roxb (SR) extract on heart weight, plasma lipid profile, plasma marker enzymes, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants and membrane bound ATPases against isoproterenol (IP) induced myocardial necrosis (MN) in rats. Rats treated with IP (85mg/kg, s.c.) recorded significant (p<0.05) increment in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation (LPO) and activity levels of Ca+2 ATPase whereas there was significant (p<0.05) decrease in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase. Pre-treatment with SR extract (400mg/kg per day, p.o.) for 30 consecutive days followed by IP injections on days 29th and 30th, showed significant (p<0.05) decrease in heart weight, plasma lipid profile, plasma marker enzymes of cardiac damage, cardiac lipid peroxidation, Ca+2 ATPase and significant increase in plasma HDL, cardiac endogenous enzymatic and non-enzymatic antioxidants, Na+-K+ ATPase and Mg+2 ATPase compared to IP treated group. Hence, this study is the first scientific report on cardioprotective effect of SR against IP induced MN in rats.

KW - Isoproterenol

KW - Myocardial infarction

KW - Sida rhomboidea. Roxb

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VL - 63

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JO - Experimental and Toxicologic Pathology

JF - Experimental and Toxicologic Pathology

IS - 4

ER -

Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats

Abstract

Keywords

ASJC Scopus subject areas

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