Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

R. W. Rockhold; R. W. Caldwell

doi:10.1016/0028-3908(80)90094-5

Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

R. W. Rockhold, R. W. Caldwell

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Clonidine microinjection into the mediocaudal region of the nucleus tractus solitarii (NTS) of the rat elicited dose-related (1.25–40.0 nmol) hypotension and bradycardia following NTS application. Cardiovascular effects produced by NTS injection of 5 nmol clonidine could be abolished by NTS pretreatment with the α₂-adrenoceptor blocker, yohimbine (10 nmol). Dorsal medullary areas surrounding the NTS responded to clonidine microinjection with blood pressure falls similar to that seen after NTS microinjection. Bradycardic responses, however, were elicited more selectively from areas within anatomic boundaries of the NTS. These data suggest that, while blood pressure decreases can be demonstrated following direct application of clonidine into the medio-caudal NTS, the major interaction of clonidine with the NTS in the rat is to produce a decrease in heart rate.

Original language	English (US)
Pages (from-to)	919-922
Number of pages	4
Journal	Neuropharmacology
Volume	19
Issue number	9
DOIs	https://doi.org/10.1016/0028-3908(80)90094-5
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(80)90094-5

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@article{5dc34c2da5e64e9b95a798001c3b4728,

title = "Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat",

abstract = "Clonidine microinjection into the mediocaudal region of the nucleus tractus solitarii (NTS) of the rat elicited dose-related (1.25–40.0 nmol) hypotension and bradycardia following NTS application. Cardiovascular effects produced by NTS injection of 5 nmol clonidine could be abolished by NTS pretreatment with the α2-adrenoceptor blocker, yohimbine (10 nmol). Dorsal medullary areas surrounding the NTS responded to clonidine microinjection with blood pressure falls similar to that seen after NTS microinjection. Bradycardic responses, however, were elicited more selectively from areas within anatomic boundaries of the NTS. These data suggest that, while blood pressure decreases can be demonstrated following direct application of clonidine into the medio-caudal NTS, the major interaction of clonidine with the NTS in the rat is to produce a decrease in heart rate.",

author = "Rockhold, {R. W.} and Caldwell, {R. W.}",

note = "Funding Information: These studies were supported by grants from the American and Tennessee Heart Associations. Clonidine was generously supplied by Boehringer-Ingelheim, Ltd. We would like to acknowledge the excellent technical assistance of Mrs. Anna Sulser-Newton. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1980",

doi = "10.1016/0028-3908(80)90094-5",

language = "English (US)",

volume = "19",

pages = "919--922",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Limited",

number = "9",

}

TY - JOUR

T1 - Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

AU - Rockhold, R. W.

AU - Caldwell, R. W.

N1 - Funding Information: These studies were supported by grants from the American and Tennessee Heart Associations. Clonidine was generously supplied by Boehringer-Ingelheim, Ltd. We would like to acknowledge the excellent technical assistance of Mrs. Anna Sulser-Newton. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1980

Y1 - 1980

N2 - Clonidine microinjection into the mediocaudal region of the nucleus tractus solitarii (NTS) of the rat elicited dose-related (1.25–40.0 nmol) hypotension and bradycardia following NTS application. Cardiovascular effects produced by NTS injection of 5 nmol clonidine could be abolished by NTS pretreatment with the α2-adrenoceptor blocker, yohimbine (10 nmol). Dorsal medullary areas surrounding the NTS responded to clonidine microinjection with blood pressure falls similar to that seen after NTS microinjection. Bradycardic responses, however, were elicited more selectively from areas within anatomic boundaries of the NTS. These data suggest that, while blood pressure decreases can be demonstrated following direct application of clonidine into the medio-caudal NTS, the major interaction of clonidine with the NTS in the rat is to produce a decrease in heart rate.

AB - Clonidine microinjection into the mediocaudal region of the nucleus tractus solitarii (NTS) of the rat elicited dose-related (1.25–40.0 nmol) hypotension and bradycardia following NTS application. Cardiovascular effects produced by NTS injection of 5 nmol clonidine could be abolished by NTS pretreatment with the α2-adrenoceptor blocker, yohimbine (10 nmol). Dorsal medullary areas surrounding the NTS responded to clonidine microinjection with blood pressure falls similar to that seen after NTS microinjection. Bradycardic responses, however, were elicited more selectively from areas within anatomic boundaries of the NTS. These data suggest that, while blood pressure decreases can be demonstrated following direct application of clonidine into the medio-caudal NTS, the major interaction of clonidine with the NTS in the rat is to produce a decrease in heart rate.

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AN - SCOPUS:0018883586

SN - 0028-3908

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SP - 919

EP - 922

JO - Neuropharmacology

JF - Neuropharmacology

IS - 9

ER -

Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

Abstract

ASJC Scopus subject areas

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