Cardiovascular Toxicities Associated with Tyrosine Kinase Inhibitors

Nicolas Sayegh, Juliet Yirerong, Neeraj Agarwal, Daniel Addison, Michael Fradley, Jorge Cortes, Neal L. Weintraub, Nazish Sayed, Girindra Raval, Avirup Guha

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: To provide a detailed overview of cardiovascular adverse events associated with the use of tyrosine kinase inhibitors across different tumor types. Recent Findings: Despite an undeniable survival advantage of tyrosine kinase inhibitors (TKIs) in patients with hematologic or solid malignancies, the accompanying off-target cardiovascular adverse events can be life-threatening. In patients with B cell malignancies, the use of Bruton tyrosine kinase inhibitors has been associated with atrial and ventricular arrhythmias, as well as hypertension. Cardiovascular toxic profiles are heterogeneous among the several approved breakpoint cluster region (BCR)-ABL TKIS. Notably, imatinib might be cardioprotective. Vascular endothelial growth factor TKIs, constituting the central axis in the treatment of several solid tumors, including renal cell carcinoma and hepatocellular carcinoma, have strongly been associated with hypertension and arterial ischemic events. Epidermal growth factor TKIs as therapy for advanced non-small cell lung cancer (NSCLC) have been reported to be infrequently associated with heart failure and QT prolongation. Summary: While tyrosine kinase inhibitors have been demonstrated to increase overall survival across different types of cancers, special consideration should be given to cardiovascular toxicities. High-risk patients can be identified by undergoing a comprehensive workup at baseline.

Original languageEnglish (US)
Pages (from-to)269-280
Number of pages12
JournalCurrent Cardiology Reports
Issue number4
StatePublished - Apr 2023
Externally publishedYes


  • Bruton tyrosine kinase
  • Cardiovascular toxicity
  • Tyrosine kinase inhibitor
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Cardiovascular Toxicities Associated with Tyrosine Kinase Inhibitors'. Together they form a unique fingerprint.

Cite this