Carnitine homeostasis, mitochondrial function and cardiovascular disease

Shruti Sharma; Stephen M. Black

doi:10.1016/j.ddmec.2009.02.001

Carnitine homeostasis, mitochondrial function and cardiovascular disease

Shruti Sharma
, Stephen M. Black

Research output: Contribution to journal › Review article › peer-review

140 Scopus citations

Abstract

Carnitines are involved in mitochondrial transport of fatty acids and are of critical importance for maintaining normal mitochondrial function. This review summarizes recent experimental and clinical studies showing that mitochondrial dysfunction secondary to a disruption of carnitine homeostasis may play a role in decreased NO signaling and the development of endothelial dysfunction. Future challenges include development of agents that can positively modulate l-carnitine homeostasis which may have high therapeutic potential.

Original language	English (US)
Pages (from-to)	e31-e39
Journal	Drug Discovery Today: Disease Mechanisms
Volume	6
Issue number	1-4
DOIs	https://doi.org/10.1016/j.ddmec.2009.02.001
State	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmec.2009.02.001

Cite this

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title = "Carnitine homeostasis, mitochondrial function and cardiovascular disease",

abstract = "Carnitines are involved in mitochondrial transport of fatty acids and are of critical importance for maintaining normal mitochondrial function. This review summarizes recent experimental and clinical studies showing that mitochondrial dysfunction secondary to a disruption of carnitine homeostasis may play a role in decreased NO signaling and the development of endothelial dysfunction. Future challenges include development of agents that can positively modulate l-carnitine homeostasis which may have high therapeutic potential.",

author = "Shruti Sharma and Black, \{Stephen M.\}",

note = "Funding Information: This research was supported in part by grants HL60190, HL67841, HL72121, HL70061, HD039110 and HD057406 all from the National Institutes of Health to SMB, and by a grant from the Fondation Leducq to SMB.",

year = "2009",

doi = "10.1016/j.ddmec.2009.02.001",

language = "English (US)",

volume = "6",

pages = "e31--e39",

journal = "Drug Discovery Today: Disease Mechanisms",

issn = "1740-6765",

publisher = "Elsevier Ltd",

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T1 - Carnitine homeostasis, mitochondrial function and cardiovascular disease

AU - Sharma, Shruti

AU - Black, Stephen M.

N1 - Funding Information: This research was supported in part by grants HL60190, HL67841, HL72121, HL70061, HD039110 and HD057406 all from the National Institutes of Health to SMB, and by a grant from the Fondation Leducq to SMB.

PY - 2009

Y1 - 2009

N2 - Carnitines are involved in mitochondrial transport of fatty acids and are of critical importance for maintaining normal mitochondrial function. This review summarizes recent experimental and clinical studies showing that mitochondrial dysfunction secondary to a disruption of carnitine homeostasis may play a role in decreased NO signaling and the development of endothelial dysfunction. Future challenges include development of agents that can positively modulate l-carnitine homeostasis which may have high therapeutic potential.

AB - Carnitines are involved in mitochondrial transport of fatty acids and are of critical importance for maintaining normal mitochondrial function. This review summarizes recent experimental and clinical studies showing that mitochondrial dysfunction secondary to a disruption of carnitine homeostasis may play a role in decreased NO signaling and the development of endothelial dysfunction. Future challenges include development of agents that can positively modulate l-carnitine homeostasis which may have high therapeutic potential.

UR - https://www.scopus.com/pages/publications/77956649059

UR - https://www.scopus.com/pages/publications/77956649059#tab=citedBy

U2 - 10.1016/j.ddmec.2009.02.001

DO - 10.1016/j.ddmec.2009.02.001

M3 - Review article

AN - SCOPUS:77956649059

SN - 1740-6765

VL - 6

SP - e31-e39

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 1-4

ER -

Carnitine homeostasis, mitochondrial function and cardiovascular disease

Abstract

UN SDGs

ASJC Scopus subject areas

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