Carrier-mediated transport of glycyl-L-proline in renal brush border vesicles

Vadivel Ganapathy, Joseph Mendicino, David H. Pashley, Frederick H. Leibach

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Renal brush border vesicles prepared from rabbit were shown to transport intact glycyl-L-proline into the intravesicular space by a Na+-independent, carrier-mediated process. The kinetics of hydrolysis of glycyl-L-proline by the vesicles showed that this dipeptide was extremely resistant to hydrolysis. The intravesicular concentration of glycyl-L-proline was the same in both NaCl and KCl media. Dipeptide uptake into the vesicles appeared to be via carrier-mediated transport down a concentration gradient.

Original languageEnglish (US)
Pages (from-to)1133-1139
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Dec 16 1980

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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