TY - JOUR
T1 - Case report
T2 - Castleman disease in association with POEMS
AU - Adelman, H. M.
AU - Cacciatore, M. L.
AU - Pascual, J. F.
AU - Mike, J. M.
AU - Alberts, W. M.
AU - Wallach, P. M.
PY - 1994
Y1 - 1994
N2 - Castleman disease, or angiofollicular lymph node hyperplasia, and POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes), are associated and can lead to a clinical conundrum. The physician caring for a patient with Castleman disease should be alert to the development of multiple endocrine deficiencies, including primary hypogonadism, diabetes mellitus, hypothyroidism, and adrenal insufficiency. Avoidance of treating hypothyroidism alone when there is concomitant subclinical adrenal insufficiency is important, to avoid precipitating an adrenal crisis. A better outcome may result from earlier recognition of the endocrinopathies of this syndrome. This article describes a patient with Castleman disease in whom the features of POEMS unfolded over the ensuing years.
AB - Castleman disease, or angiofollicular lymph node hyperplasia, and POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes), are associated and can lead to a clinical conundrum. The physician caring for a patient with Castleman disease should be alert to the development of multiple endocrine deficiencies, including primary hypogonadism, diabetes mellitus, hypothyroidism, and adrenal insufficiency. Avoidance of treating hypothyroidism alone when there is concomitant subclinical adrenal insufficiency is important, to avoid precipitating an adrenal crisis. A better outcome may result from earlier recognition of the endocrinopathies of this syndrome. This article describes a patient with Castleman disease in whom the features of POEMS unfolded over the ensuing years.
UR - http://www.scopus.com/inward/record.url?scp=0028045031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028045031&partnerID=8YFLogxK
U2 - 10.1097/00000441-199402000-00008
DO - 10.1097/00000441-199402000-00008
M3 - Article
C2 - 8141136
AN - SCOPUS:0028045031
SN - 0002-9629
VL - 307
SP - 112
EP - 114
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -