CD63 positions CD62P for rolling

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations


Doyle and colleagues identify the tetraspanin CD63 as an essential co-factor for endothelial P-selectin function.1 In the absence of CD63 (by knockout in mice or knockdown in cultured endothelial cells), P-selectin (also known as CD62P) cannot mediate leukocyte tethering and rolling. This surprising finding suggests that Pselectin must be positioned in organized membrane microdomains to function.

Original languageEnglish (US)
Pages (from-to)4012-4013
Number of pages2
Issue number15
StatePublished - Oct 13 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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