CD63 positions CD62P for rolling

Klaus Ley

doi:10.1182/blood-2011-08-372318

CD63 positions CD62P for rolling

Klaus Ley

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Doyle and colleagues identify the tetraspanin CD63 as an essential co-factor for endothelial P-selectin function.¹ In the absence of CD63 (by knockout in mice or knockdown in cultured endothelial cells), P-selectin (also known as CD62P) cannot mediate leukocyte tethering and rolling. This surprising finding suggests that Pselectin must be positioned in organized membrane microdomains to function.

Original language	English (US)
Pages (from-to)	4012-4013
Number of pages	2
Journal	Blood
Volume	118
Issue number	15
DOIs	https://doi.org/10.1182/blood-2011-08-372318
State	Published - Oct 13 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood-2011-08-372318

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title = "CD63 positions CD62P for rolling",

abstract = "Doyle and colleagues identify the tetraspanin CD63 as an essential co-factor for endothelial P-selectin function.1 In the absence of CD63 (by knockout in mice or knockdown in cultured endothelial cells), P-selectin (also known as CD62P) cannot mediate leukocyte tethering and rolling. This surprising finding suggests that Pselectin must be positioned in organized membrane microdomains to function.",

author = "Klaus Ley",

year = "2011",

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doi = "10.1182/blood-2011-08-372318",

language = "English (US)",

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publisher = "American Society of Hematology",

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T1 - CD63 positions CD62P for rolling

AU - Ley, Klaus

PY - 2011/10/13

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N2 - Doyle and colleagues identify the tetraspanin CD63 as an essential co-factor for endothelial P-selectin function.1 In the absence of CD63 (by knockout in mice or knockdown in cultured endothelial cells), P-selectin (also known as CD62P) cannot mediate leukocyte tethering and rolling. This surprising finding suggests that Pselectin must be positioned in organized membrane microdomains to function.

AB - Doyle and colleagues identify the tetraspanin CD63 as an essential co-factor for endothelial P-selectin function.1 In the absence of CD63 (by knockout in mice or knockdown in cultured endothelial cells), P-selectin (also known as CD62P) cannot mediate leukocyte tethering and rolling. This surprising finding suggests that Pselectin must be positioned in organized membrane microdomains to function.

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U2 - 10.1182/blood-2011-08-372318

DO - 10.1182/blood-2011-08-372318

M3 - Comment/debate

AN - SCOPUS:80054118662

SN - 0006-4971

VL - 118

SP - 4012

EP - 4013

JO - Blood

JF - Blood

IS - 15

ER -

CD63 positions CD62P for rolling

Abstract

ASJC Scopus subject areas

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