CD73 on cancer-associated fibroblasts enhanced by the A_2B-mediated feedforward circuit enforces an immune checkpoint

Keyphrases

• Cancer-associated Fibroblasts 100%
• CD73 100%
• Immune Checkpoint 100%
• Feedforward Circuit 100%
• Adenosine 20%
• Tumor 10%
• Tumor Tissue 10%
• In Cancer 10%
• Receptor-mediated 10%
• Colorectal Cancer 10%
• Human Colorectal Cancer 10%
• Immune Suppression 10%
• Poor Prognosis 10%
• Poor Clinical Outcomes 10%
• Tumor Immunity 10%
• Immune Activation 10%
• Dual Inhibition 10%
• A2B Adenosine Receptor 10%
• A2A Receptor 10%
• Murine Tumor Model 10%
• Tumor Microenvironment 10%
• Therapeutic Outcome 10%
• Tumor Cell Death 10%
• Ectonucleotidases 10%
• Colorectal Tissue 10%
• Abundancy 10%
• NT5E 10%

Biochemistry, Genetics and Molecular Biology

• Fibroblast 100%
• Immune Checkpoints 100%
• Adenosine 33%
• Cell Death 16%
• Eicosanoid Receptor 16%
• Murine 16%
• Adenosine A2B Receptor 16%
• Nucleotidase 16%
• NT5E 16%

Immunology and Microbiology

• Cancer Associated Fibroblast 100%
• Cell Death 16%
• Tumor Cell 16%
• Neutralization 16%
• Murine 16%
• Cancer Tissue 16%
• 5' Nucleotidase 16%
• NT5E 16%