CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated

Keyphrases

• Glioblastoma 100%
• Cyclin-dependent Kinase Inhibitor 2A (CDKN2A) 100%
• Anaplastic Astrocytoma 50%
• Cyclin-dependent Kinase 4 (CDK4) 37%
• RB Gene 37%
• Tumor Suppressor Gene 25%
• Allelic Loss 25%
• Cyclin D1 (CCND1) 25%
• Chromosome 9p 25%
• P16 Gene 25%
• Chromosome 13q 25%
• Genetic Changes 12%
• Astrocytes 12%
• Retinoblastoma 12%
• Gene Amplification 12%
• Glioma 12%
• Glioblastoma multiforme 12%
• DNA Sequence Analysis 12%
• Gene mutation 12%
• Homozygous Deletion 12%
• Single-strand Conformation Polymorphism 12%
• Human Glioblastoma 12%
• Coding Exons 12%
• Frameshift mutation 12%
• Regulatory Cascade 12%
• Glioblastoma multiforme Cells 12%
• Astrocytoma 12%
• Gene Loss 12%
• Multiplex PCR (mPCR) 12%
• Gene Abnormality 12%
• Corroborative Evidence 12%
• Glioma Tumor 12%
• Microsatellite Polymorphism 12%
• Oncogenic Effect 12%

Biochemistry, Genetics and Molecular Biology

• P16 100%
• Tumor Suppressor Gene 33%
• Gene Mutation 22%
• Cyclin D1 22%
• Chromosome 9p 22%
• Chromosome 13q 22%
• Allele 11%
• Cell Cycle 11%
• DNA Sequence 11%
• Carcinogenesis 11%
• Exon 11%
• Astrocyte 11%
• Retinoblastoma 11%
• Cyclin-Dependent Kinase 4 11%
• Single-Strand Conformation Polymorphism 11%
• Gene Loss 11%
• Gene Amplification 11%
• Frameshift Mutation 11%
• Multiplex Polymerase Chain Reaction 11%
• Microsatellite 11%