cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

C. Betsholtz; A. Johnsson; C. H. Heldin; B. Westermark; P. Lind; M. S. Urdea; R. Eddy; T. B. Shows; K. Philpott; A. L. Mellor

doi:10.1038/320695a0

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

C. Betsholtz
, A. Johnsson
, C. H. Heldin
, B. Westermark
, P. Lind
, M. S. Urdea
, R. Eddy
, T. B. Shows
, K. Philpott
, A. L. Mellor

Infectious Disease

Research output: Contribution to journal › Article › peer-review

615 Scopus citations

Abstract

The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.

Original language	English (US)
Pages (from-to)	695-699
Number of pages	5
Journal	Nature
Volume	320
Issue number	6064
DOIs	https://doi.org/10.1038/320695a0
State	Published - 1986

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title = "cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines",

abstract = "The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.",

author = "C. Betsholtz and A. Johnsson and Heldin, \{C. H.\} and B. Westermark and P. Lind and Urdea, \{M. S.\} and R. Eddy and Shows, \{T. B.\} and K. Philpott and Mellor, \{A. L.\}",

year = "1986",

doi = "10.1038/320695a0",

language = "English (US)",

volume = "320",

pages = "695--699",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6064",

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TY - JOUR

T1 - cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

AU - Betsholtz, C.

AU - Johnsson, A.

AU - Heldin, C. H.

AU - Westermark, B.

AU - Lind, P.

AU - Urdea, M. S.

AU - Eddy, R.

AU - Shows, T. B.

AU - Philpott, K.

AU - Mellor, A. L.

PY - 1986

Y1 - 1986

N2 - The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.

AB - The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.

UR - https://www.scopus.com/pages/publications/0022447025

UR - https://www.scopus.com/pages/publications/0022447025#tab=citedBy

U2 - 10.1038/320695a0

DO - 10.1038/320695a0

M3 - Article

C2 - 3754619

AN - SCOPUS:0022447025

SN - 0028-0836

VL - 320

SP - 695

EP - 699

JO - Nature

JF - Nature

IS - 6064

ER -

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

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