Cell adhesion under flow.

Research output: Contribution to journalEditorialpeer-review

4 Scopus citations


Cell adhesion under flow is a central function of the microcirculation during inflammation, hemostasis, and immune regulation. This special issue of Microcirculation explores the common and distinct mechanisms that myeloid cells, lymphocytes, platelets, and sickle erythrocytes use to adhere to microvascular endothelium and the underlying basement membrane structures. A common theme in these processes is the need for rapid integrin activation, often initiated by binding of ligands to their cognate G protein-coupled receptors, followed by adhesion strengthening associated with integrin redistribution and outside-in signaling. These elements have been identified for all cells tested except sickle erythrocytes.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
Issue number1
StatePublished - Jan 2009
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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