Abstract
The Ras-like Rab1 and Rab6 GTPases modulate protein traffic along the ely secretory pathway and e involved in the regulation of maturation of rhodopsin in the outer retina. However, Rab GTPases have not been studied in the inner retinas. Here, we analyzed the anatomatic distribution and expression of Rab1 and Rab6 in the mouse and rat retinas by immunohistochemistry and immunoblotting. We found that Rab1 was specifically expressed in the rod bipol cells, while Rab6 was expressed in a different cell type(s) from rod bipol cells in the inner retina. We also demonstrated that expression of Rab1 and Rab6 was increased with light. These data provided the first evidence implicating that Rab1 and Rab6 may be involved in the regulation of the retinal adaptation.
Original language | English (US) |
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Pages (from-to) | 443-452 |
Number of pages | 10 |
Journal | Visual Neuroscience |
Volume | 26 |
Issue number | 5-6 |
DOIs | |
State | Published - Nov 2009 |
Keywords
- Inner nucle layer
- Müller Cell
- Protein kinase C
- Retinal adaptation
- Rod bipol cell
ASJC Scopus subject areas
- Physiology
- Sensory Systems