Cellular metabolism: Contribution to postoperative adhesion development

Valerie I. Shavell, Ghassan M. Saed, Michael P. Diamond

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Postoperative adhesions are a significant source of morbidity, including contributions to pelvic pain, bowel obstruction, and infertility. While the mechanisms of postoperative adhesion development are complex and incompletely understood, hypoxia appears to trigger a cascade of intracellular responses involving hypoxia-inducible factors, lactate, reactive oxygen species, reactive nitrogen species, and insulin-like growth factors that results in manifestation of the adhesion phenotype. Thus, substantial evidence exists to implicate the direct role of cellular metabolism in wound repair and adhesion development.

Original languageEnglish (US)
Pages (from-to)627-634
Number of pages8
JournalReproductive Sciences
Issue number7
StatePublished - Jul 2009
Externally publishedYes


  • Adhesions
  • Apoptosis
  • Hypoxia
  • Hypoxia-inducible factor (HIF)
  • Lactate
  • Reactive oxygen species

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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