@inproceedings{34e17cf75c994ad7935c4716a7ea4cde,
title = "Characterization of PAF-AH Ib1 in NOD mice: PAF-AH may not be a candidate gene of the diabetes susceptibility Idd4.1 locus",
abstract = "We recently mapped Idd4 to a 5.2 cM interval on chromosome 11 with two subloci, Idd4.1 and Idd4.2, in nonobese diabetic (NOD) mice. Based on the localization of platelet-activating factor acetylhydrolase Ib1 (PAF-AHIb1) and the decreased activity of PAF-AH in type 1 diabetes (T1D) patients, we hypothesized that PAF-AHIb1 in Idd4.1 is a candidate gene. The PAF-AHIb1 gene in NOD mice was cloned and sequenced, and its expression and function were studied. No polymorphisms were detected in PAF-AHIb1 cDNA between NOD and B6 mice. The expression of PAF-AH Ib1 at the mRNA and protein levels was found to be similar in different tissues between NOD and B6 mice. PAF-AH activity does not differ in the pancreatic islets or spleen between NOD and B6 mice. Our findings suggest that PAF-AH Ib1 may not be a diabetes-susceptibility gene in the Idd4.1 sublocus.",
keywords = "Diabetes, Genetic susceptibility, Idd4, Nonobese diabetic mice, Platelet-activating factor acetylhydrolase Ib1 gene",
author = "Mi, {Qing Sheng} and Li Zhou and Marsha Grattan and Wang, {Zai Zhao} and M. Sivilotti and Jin-Xiong She and Delovitch, {Terry L.}",
year = "2006",
month = oct,
doi = "10.1196/annals.1375.022",
language = "English (US)",
isbn = "1573316415",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "147--152",
booktitle = "Immunology of Diabetes IV",
}