Characterization of the interaction between phthalocyanine and amyloid fibrils by surface-enhanced Raman scattering (SERS)

Mykhaylo Yu Losytskyy, Nuriye Akbay, Svitlana Chernii, Ertug Avcı, Viktor Chernii, Sergiy Yarmoluk, Mustafa Culha, Vladyslava Kovalska

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The applicability of surface-enhanced Raman scattering (SERS) on silver nanoparticles for characterization of interaction between the phthalocyanine molecule and amyloid fibril was studied using the axially coordinated Hf phthalocyanine dichloride and fibrils of amyloidogenic protein insulin. The SERS spectra of the phthalocyanine were obtained; the analytical enhancement factor was estimated to be in the range from 4 to 6 ×104. An intensity enhancement in its SERS spectra caused by the presence of fibrillar insulin was observed. Deviation of this enhancement with the change of fibrillar insulin concentration was manifested.

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalAnalytical Letters
Volume51
Issue number1-2
DOIs
StatePublished - Oct 28 2018
Externally publishedYes

Keywords

  • Amyloid fibrils
  • Insulin
  • Phthalocyanine
  • Surfaceenhanced Raman scattering (SERS)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry

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