Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity

Repository, Other contributors, The TEDDY study group, Colorado Clinical Center, Finland Clinical Center, Georgia/Florida Clinical Center, Germany Clinical Center, Sweden Clinical Center, Washington Clinical Center, Pennsylvania Satellite Center, Data Coordinating Center, Past staff, Autoantibody Reference Laboratories, Dietary Biomarkers Laboratory, HLA Reference Laboratory, SNP Laboratory

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case–control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n − 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n − 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.

Original languageEnglish (US)
Article number3627
JournalScientific reports
Issue number1
StatePublished - Dec 2021
Externally publishedYes

ASJC Scopus subject areas

  • General


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