TY - JOUR
T1 - Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
AU - Repository
AU - Other contributors
AU - The TEDDY study group
AU - Colorado Clinical Center
AU - Finland Clinical Center
AU - Georgia/Florida Clinical Center
AU - Germany Clinical Center
AU - Sweden Clinical Center
AU - Washington Clinical Center
AU - Pennsylvania Satellite Center
AU - Data Coordinating Center
AU - Past staff
AU - Autoantibody Reference Laboratories
AU - Dietary Biomarkers Laboratory
AU - HLA Reference Laboratory
AU - SNP Laboratory
AU - Niinistö, Sari
AU - Erlund, Iris
AU - Lee, Hye Seung
AU - Uusitalo, Ulla
AU - Salminen, Irma
AU - Aronsson, Carin Andrén
AU - Parikh, Hemang M.
AU - Liu, Xiang
AU - Hummel, Sandra
AU - Toppari, Jorma
AU - She, Jin Xiong
AU - Lernmark, Åke
AU - Ziegler, Annette G.
AU - Rewers, Marian
AU - Akolkar, Beena
AU - Krischer, Jeffrey P.
AU - Galas, David
AU - Das, Siba
AU - Sakhanenko, Nikita
AU - Rich, Stephen S.
AU - Hagopian, William
AU - Norris, Jill M.
AU - Virtanen, Suvi M.
AU - Barbour, Aaron
AU - Bautista, Kimberly
AU - Baxter, Judith
AU - Felipe-Morales, Daniel
AU - Driscoll, Kimberly
AU - Frohnert, Brigitte I.
AU - Stahl, Marisa
AU - Gesualdo, Patricia
AU - Hoffman, Michelle
AU - Karban, Rachel
AU - Liu, Edwin
AU - Peacock, Stesha
AU - Shorrosh, Hanan
AU - Steck, Andrea
AU - Stern, Megan
AU - Villegas, Erica
AU - Waugh, Kathleen
AU - Simell, Olli G.
AU - Adamsson, Annika
AU - Ahonen, Suvi
AU - Åkerlund, Mari
AU - Hakola, Leena
AU - Hekkala, Anne
AU - Holappa, Henna
AU - Hyöty, Heikki
AU - McIndoe, Richard
AU - Sharma, Ashok
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case–control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n − 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n − 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.
AB - Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case–control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n − 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n − 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.
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U2 - 10.1038/s41598-021-82200-9
DO - 10.1038/s41598-021-82200-9
M3 - Article
C2 - 33574451
AN - SCOPUS:85101050436
SN - 2045-2322
VL - 11
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 3627
ER -
