Chromophore-assisted laser inactivation in cell biology

Ken Jacobson, Zenon Rajfur, Eric Vitriol, Klaus Hahn

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


Chromophore-assisted laser inactivation (CALI) is a technique whereby engineered proteins and dye molecules that produce substantial amounts of reactive oxygen species upon absorption of light are used to perturb biological systems in a spatially and temporally defined manner. CALI is an important complement to conventional genetic and pharmacological manipulations. In this review, we examine the applications of CALI to cell biology and discuss the underlying photochemical mechanisms that mediate this powerful technique.

Original languageEnglish (US)
Pages (from-to)443-450
Number of pages8
JournalTrends in Cell Biology
Issue number9
StatePublished - Sep 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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