@article{96230c9b28354a9d946ebfb1a7050bfe,
title = "Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress",
abstract = "Chronic stress-induced anxiety disorder is a highly-prevalent, modern social disease in which oxidative stress plays an important role. It is necessary to determine the underlying mechanisms governing this disorder to establish an effective treatment target for anxiety disorders. In this study, we examined the behavioral changes in mice subjected to chronic mild stress (CMS). We found that CMS exposure leads to anxiety-like phenotypes and increased levels of oxidative stress in the ventral hippocampus of mice. Furthermore, CMS increased the excitatory synaptic transmission of pyramidal cells in the ventral CA1 (vCA1). Administration of 4-hydroxy-3-methoxy-acetophenone (apocynin), an inhibitor of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, clearly ameliorated the changes induced by CMS exposure. In addition, our results of behavioral tests and analyses of reactive oxygen species (ROS) using NOX2-deficient mice indicate that CMS-induced enhanced oxidative stress level is primarily caused by the increased expression of NOX2. NOX2-derived oxidative stress can serve as a target for anxiety therapy led by chronic stress.",
keywords = "Anxiety, Chronic mild stress, Microglia, NOX2, Oxidative stress, Ventral CA1",
author = "Hang Lv and Chuan'an Zhu and Ruolin Wu and Hui Ni and Jiating Lian and Yunlong Xu and Yucen Xia and Guoqi Shi and Zhixing Li and Caldwell, {Ruth B.} and Caldwell, {Robert William} and Lin Yao and Yongjun Chen",
note = "Funding Information: This work was funded by National Natural Science Fund of China (31571041 and 31600937), Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2016 A1-AFD018181Z3903), Scientific Research and Innovation Team Program of Guangzhou University of Chinese Medicine (2017KYTD03), Innovation Team Program of Guangdong Provincial Department of education (2017KCXTD006), and Research Grant of Guangdong Province Key Laboratory of Psychiatric Disorders (N201801). Funding Information: This work was funded by National Natural Science Fund of China ( 31571041 and 31600937 ), Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme ( 2016 A1-AFD018181Z3903 ), Scientific Research and Innovation Team Program of Guangzhou University of Chinese Medicine ( 2017KYTD03 ), Innovation Team Program of Guangdong Provincial Department of education ( 2017KCXTD006 ), and Research Grant of Guangdong Province Key Laboratory of Psychiatric Disorders ( N201801 ). Publisher Copyright: {\textcopyright} 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = jul,
doi = "10.1016/j.jpsychires.2019.04.008",
language = "English (US)",
volume = "114",
pages = "55--66",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
}