TY - JOUR
T1 - Chronic myeloid leukemia
T2 - Reminiscences and dreams
AU - Mughal, Tariq I.
AU - Radich, Jerald P.
AU - Deininger, Michael W.
AU - Apperley, Jane F.
AU - Hughes, Timothy P.
AU - Harrison, Christine J.
AU - Gambacorti-Passerini, Carlo
AU - Saglio, Giuseppe
AU - Cortes, Jorge
AU - Daley, George Q.
N1 - Publisher Copyright:
© 2016 Ferrata Storti Foundation.
PY - 2016/4/30
Y1 - 2016/4/30
N2 - With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the cytogenetic anatomy of the Philadelphia chromosome, which subsequently led to the identification of the BCR-ABL1 fusion gene and its principal pathogenetic role in the development of chronic myeloid leukemia. This work was also of major importance to support the idea that cytogenetic changes were drivers of leukemogenesis. John Goldman originally made seminal contributions to the use of autologous and allogeneic stem cell transplantation from the late 1970s onwards. Then, in collaboration with Brian Druker, he led efforts to develop ABL1 tyrosine kinase inhibitors for the treatment of patients with chronic myeloid leukemia in the late 1990s. He also led the global efforts to develop and harmonize methodology for molecular monitoring, and was an indefatigable organizer of international conferences. These conferences brought together clinicians and scientists, and accelerated the adoption of new therapies. The abundance of praise, tributes and testimonies expressed by many serve to illustrate the indelible impressions these two passionate and affable scholars made on so many people’s lives. This tribute provides an outline of the remarkable story of chronic myeloid leukemia, and in writing it, it is clear that the historical triumph of biomedical science over this leukemia cannot be considered without appreciating the work of both Janet Rowley and John Goldman.
AB - With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the cytogenetic anatomy of the Philadelphia chromosome, which subsequently led to the identification of the BCR-ABL1 fusion gene and its principal pathogenetic role in the development of chronic myeloid leukemia. This work was also of major importance to support the idea that cytogenetic changes were drivers of leukemogenesis. John Goldman originally made seminal contributions to the use of autologous and allogeneic stem cell transplantation from the late 1970s onwards. Then, in collaboration with Brian Druker, he led efforts to develop ABL1 tyrosine kinase inhibitors for the treatment of patients with chronic myeloid leukemia in the late 1990s. He also led the global efforts to develop and harmonize methodology for molecular monitoring, and was an indefatigable organizer of international conferences. These conferences brought together clinicians and scientists, and accelerated the adoption of new therapies. The abundance of praise, tributes and testimonies expressed by many serve to illustrate the indelible impressions these two passionate and affable scholars made on so many people’s lives. This tribute provides an outline of the remarkable story of chronic myeloid leukemia, and in writing it, it is clear that the historical triumph of biomedical science over this leukemia cannot be considered without appreciating the work of both Janet Rowley and John Goldman.
UR - http://www.scopus.com/inward/record.url?scp=84964777739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964777739&partnerID=8YFLogxK
U2 - 10.3324/haematol.2015.139337
DO - 10.3324/haematol.2015.139337
M3 - Review article
C2 - 27132280
AN - SCOPUS:84964777739
SN - 0390-6078
VL - 101
SP - 541
EP - 558
JO - Haematologica
JF - Haematologica
IS - 5
ER -