TY - JOUR
T1 - Circulating soluble E-selectin levels and the Ser128Arg polymorphism in individuals from different ethnic groups
AU - Miller, Michelle A.
AU - Kerry, Sally M.
AU - Dong, Yanbin
AU - Sagnella, Giuseppe A.
AU - Cook, Derek G.
AU - Cappuccio, Francesco P.
N1 - Funding Information:
This study was supported by the British Heart Foundation (Project Grant/2001023). A list of the WHSS Group is given elsewhere [18] . We thank Dr. Haidong Zhu for technical advice and Kelly Gormley for sequence analysis. We thank Professor N. Carter for the use of the laboratory facilities and Professor P. Strazzullo for the biochemical measurements. The WHSS has received support from the former Wandsworth and South Thames Regional Health Authorities, NHS R & D Directorate, British Heart Foundation, former British Diabetic Association and The Stroke Association. Dr. Miller was supported by the British Heart Foundation, the EU (QLK1-CT-2000-00100) and by The Wellcome Trust VIP Award. MAM, GAS, DGC and FPC are members of the St. George's Cardiovascular Research Group.
PY - 2005/2
Y1 - 2005/2
N2 - Background and aim: An association between the Ser128Arg polymorphism and coronary heart disease (CHD) has been previously demonstrated in a white population. The aim of this study was to investigate whether the Ser128Arg polymorphism of the E-selectin gene is associated with soluble E-selectin levels in individuals from a multiethnic population. Methods and results: Plasma sE-selectin levels and the Ser128Arg E-selectin gene polymorphism were determined in 244 white (109 females), 176 of African origin (90 females) and 208 South Asian (95 females) healthy individuals living in England selected from the Wandsworth Heart and Stroke Study (WHSS). The substitution of serine for arginine (A to C mutation) was more common in whites (9.6%) and South Asians (7.9%) compared to the people of African origin (3.7%); p = 0.005. The C mutation had no effect on sE-selectin levels in any ethnic group. Conclusions: We found a lower frequency of this polymorphism in the people of African origin who have a low CHD risk. However, in this study the polymorphism was not associated with circulating sE-selectin levels. Whether it plays a role in determining ethnic differences in vascular disease via a mechanism affecting leukocyte recruitment remains to be determined.
AB - Background and aim: An association between the Ser128Arg polymorphism and coronary heart disease (CHD) has been previously demonstrated in a white population. The aim of this study was to investigate whether the Ser128Arg polymorphism of the E-selectin gene is associated with soluble E-selectin levels in individuals from a multiethnic population. Methods and results: Plasma sE-selectin levels and the Ser128Arg E-selectin gene polymorphism were determined in 244 white (109 females), 176 of African origin (90 females) and 208 South Asian (95 females) healthy individuals living in England selected from the Wandsworth Heart and Stroke Study (WHSS). The substitution of serine for arginine (A to C mutation) was more common in whites (9.6%) and South Asians (7.9%) compared to the people of African origin (3.7%); p = 0.005. The C mutation had no effect on sE-selectin levels in any ethnic group. Conclusions: We found a lower frequency of this polymorphism in the people of African origin who have a low CHD risk. However, in this study the polymorphism was not associated with circulating sE-selectin levels. Whether it plays a role in determining ethnic differences in vascular disease via a mechanism affecting leukocyte recruitment remains to be determined.
KW - Cardiovascular disease
KW - Cell adhesion molecules
KW - Ethnicity
KW - Polymorphism
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U2 - 10.1016/j.numecd.2004.05.002
DO - 10.1016/j.numecd.2004.05.002
M3 - Article
C2 - 15871853
AN - SCOPUS:17444385664
SN - 0939-4753
VL - 15
SP - 65
EP - 70
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 1
ER -