Clerodendron glandulosum.Coleb extract prevents in vitro human LDL oxidation and oxidized LDL induced apoptosis in human monocyte derived macrophages

Ravirajsinh N. Jadeja; Menaka C. Thounaojam; Ranjisinh V. Devkar; A. V. Ramachandran

doi:10.1016/j.fct.2011.02.017

Clerodendron glandulosum.Coleb extract prevents in vitro human LDL oxidation and oxidized LDL induced apoptosis in human monocyte derived macrophages

Ravirajsinh N. Jadeja
, Menaka C. Thounaojam
, Ranjisinh V. Devkar
, A. V. Ramachandran

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

This study reports the protective role of Clerodendron glandulosum (CG) extract against in vitro LDL oxidation and Ox-LDL induced macrophage apoptosis using various experimental models. Effect of CG extract on Cu²⁺ mediated LDL oxidation kinetics and formation of various intermediary products and its ability to prevent human monocyte derived macrophage mediated LDL oxidation have been investigated. Ox-LDL induced macrophage apoptosis was evaluated by nuclear condensation, cell cycle analysis, and annexin V-FITC/PI staining in presence or absence of CG extract. Results recorded in the present study clearly suggest the protective role of CG extract against LDL oxidation and Ox-LDL induced macrophage oxidative stress, mitochondrial dysfunction, and apoptosis. This is the first report on the protective role of CG extract on two key events of atherosclerosis portending its possible therapeutic use as an anti-atherogenic herbal medicine.

Original language	English (US)
Pages (from-to)	1195-1202
Number of pages	8
Journal	Food and Chemical Toxicology
Volume	49
Issue number	6
DOIs	https://doi.org/10.1016/j.fct.2011.02.017
State	Published - Jun 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Clerodenron glandulosum.Coleb
LDL oxidation
Macrophage
Oxidative stress

ASJC Scopus subject areas

Food Science
Toxicology

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10.1016/j.fct.2011.02.017

Cite this

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title = "Clerodendron glandulosum.Coleb extract prevents in vitro human LDL oxidation and oxidized LDL induced apoptosis in human monocyte derived macrophages",

abstract = "This study reports the protective role of Clerodendron glandulosum (CG) extract against in vitro LDL oxidation and Ox-LDL induced macrophage apoptosis using various experimental models. Effect of CG extract on Cu2+ mediated LDL oxidation kinetics and formation of various intermediary products and its ability to prevent human monocyte derived macrophage mediated LDL oxidation have been investigated. Ox-LDL induced macrophage apoptosis was evaluated by nuclear condensation, cell cycle analysis, and annexin V-FITC/PI staining in presence or absence of CG extract. Results recorded in the present study clearly suggest the protective role of CG extract against LDL oxidation and Ox-LDL induced macrophage oxidative stress, mitochondrial dysfunction, and apoptosis. This is the first report on the protective role of CG extract on two key events of atherosclerosis portending its possible therapeutic use as an anti-atherogenic herbal medicine.",

keywords = "Apoptosis, Clerodenron glandulosum.Coleb, LDL oxidation, Macrophage, Oxidative stress",

author = "Jadeja, \{Ravirajsinh N.\} and Thounaojam, \{Menaka C.\} and Devkar, \{Ranjisinh V.\} and Ramachandran, \{A. V.\}",

year = "2011",

month = jun,

doi = "10.1016/j.fct.2011.02.017",

language = "English (US)",

volume = "49",

pages = "1195--1202",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Ltd",

number = "6",

}

TY - JOUR

T1 - Clerodendron glandulosum.Coleb extract prevents in vitro human LDL oxidation and oxidized LDL induced apoptosis in human monocyte derived macrophages

AU - Jadeja, Ravirajsinh N.

AU - Thounaojam, Menaka C.

AU - Devkar, Ranjisinh V.

AU - Ramachandran, A. V.

PY - 2011/6

Y1 - 2011/6

N2 - This study reports the protective role of Clerodendron glandulosum (CG) extract against in vitro LDL oxidation and Ox-LDL induced macrophage apoptosis using various experimental models. Effect of CG extract on Cu2+ mediated LDL oxidation kinetics and formation of various intermediary products and its ability to prevent human monocyte derived macrophage mediated LDL oxidation have been investigated. Ox-LDL induced macrophage apoptosis was evaluated by nuclear condensation, cell cycle analysis, and annexin V-FITC/PI staining in presence or absence of CG extract. Results recorded in the present study clearly suggest the protective role of CG extract against LDL oxidation and Ox-LDL induced macrophage oxidative stress, mitochondrial dysfunction, and apoptosis. This is the first report on the protective role of CG extract on two key events of atherosclerosis portending its possible therapeutic use as an anti-atherogenic herbal medicine.

AB - This study reports the protective role of Clerodendron glandulosum (CG) extract against in vitro LDL oxidation and Ox-LDL induced macrophage apoptosis using various experimental models. Effect of CG extract on Cu2+ mediated LDL oxidation kinetics and formation of various intermediary products and its ability to prevent human monocyte derived macrophage mediated LDL oxidation have been investigated. Ox-LDL induced macrophage apoptosis was evaluated by nuclear condensation, cell cycle analysis, and annexin V-FITC/PI staining in presence or absence of CG extract. Results recorded in the present study clearly suggest the protective role of CG extract against LDL oxidation and Ox-LDL induced macrophage oxidative stress, mitochondrial dysfunction, and apoptosis. This is the first report on the protective role of CG extract on two key events of atherosclerosis portending its possible therapeutic use as an anti-atherogenic herbal medicine.

KW - Apoptosis

KW - Clerodenron glandulosum.Coleb

KW - LDL oxidation

KW - Macrophage

KW - Oxidative stress

UR - https://www.scopus.com/pages/publications/79955665037

UR - https://www.scopus.com/pages/publications/79955665037#tab=citedBy

U2 - 10.1016/j.fct.2011.02.017

DO - 10.1016/j.fct.2011.02.017

M3 - Article

C2 - 21371519

AN - SCOPUS:79955665037

SN - 0278-6915

VL - 49

SP - 1195

EP - 1202

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

IS - 6

ER -

Clerodendron glandulosum.Coleb extract prevents in vitro human LDL oxidation and oxidized LDL induced apoptosis in human monocyte derived macrophages

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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