Clinical commentary: Granulocytic fragments in sepsis

R. R. Dalton, J. S. Krauss, Dorth Greer Falls, G. K. Fuller

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Granulocytic fragments have been described in the peripheral blood of patients with sepsis and the systemic inflammatory response syndrome (SIRS). Although initially proposed as a morphologic clue for distinguishing the leukoerythroblastosis of sepsis from that of myelophthisis or marrow replacement by tumor, granulocyte-derived fragments may be part of a spectrum of cellular fragmentation associated with pathological inflammation and thrombosis, and thus play an important role in the pathophysiology of sepsis and SIRS. Pathologists, hematologists, and medical technologists should be aware of their existence, the morphologic features that distinguish them from macrothombocytes and schistocytes, and their potential significance.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalAnnals of Clinical and Laboratory Science
Issue number4
StatePublished - Nov 1 2001


  • Granulocyte
  • Microparticle
  • Neutrophil
  • Sepsis
  • Systemic inflammatory response syndrome

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology


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