Abstract
Twenty-six of fifty-eight patients undergoing autologous bone marrow transplantation (autoBMT) or peripheral stem cell transplantation (PSCT) for Hodgkin's disease had progression of lymphoma (Hodgkin's or non-Hodgkin's) during the course of their follow-up. The majority of progressions, 81% (21/26), occurred within the first year of transplant; 12% (3/26) occurred at three years or more. Three patients developed a non-Hodgkin's lymphoma; all B-cell tumors primarily involving the gastrointestinal tract. The majority of patients (23/26) received at least one therapy after progression and 65% (17/26) of patients received multiple therapies. One patient who received a second BMT is alive without evidence of disease at 49 months following the second autologous BMT. The median survival for the entire group is 11 months. Forty-six percent (12/26) of patients survived more than one year and twenty-three percent (6/26) survived more than two years after disease progression. Post-progression survival is significantly related to time to progression.
Original language | English (US) |
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Pages (from-to) | 59-65 |
Number of pages | 7 |
Journal | Leukemia and Lymphoma |
Volume | 20 |
Issue number | 1-2 |
DOIs | |
State | Published - 1995 |
Keywords
- AutoBMT
- Hodgkin's disease
- Progression
- Survival
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research