TY - JOUR
T1 - Clinical outcome of isolated locoregional recurrence in patients with breast cancer according to their primary local treatment
AU - Shenouda, Mina N.
AU - Sadek, Betro T.
AU - Goldberg, Saveli I.
AU - Keruakous, Amany R.
AU - Croft, Brandon J.
AU - Abi Raad, Rita F.
AU - Taghian, Alphonse G.
N1 - Funding Information:
This project was supported by Award Number R01CA139118 (AGT) and Award Number P50CA089393 (AGT) from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the views of the National Cancer Institute or the National Institutes of Health. All authors state that they have no conflicts of interest.
PY - 2014/6
Y1 - 2014/6
N2 - Introduction This study assessed the clinical outcome and prognostic factors in patients with breast cancer who presented with isolated locoregional recurrence (ILRR) as a first event. Materials and Methods Between 1970 and 2008, 2960 patients with pT1-2, N0-3, M0 primary invasive breast cancer had either breast-conserving therapy (BCT) using lumpectomy and radiation therapy (RT) (group A = 1849 patients) or mastectomy without RT (group B = 1111 patients). Out of groups A and B, 117 and 103 patients, respectively, developed ILRR as a first event. Those 220 patients served as the basis for this study. A multivariate analysis was performed to estimate the clinical outcome of both groups, taking into account clinically relevant variables for the primary tumor and ILRR. Results The median follow-up after ILRR was 83 months. The median disease-free interval (DFI) was 79 and 38 months for groups A and B, respectively. The overall survival (OS) for group A was 81% and 69% at 5 and 8 years, respectively. For group B, it was 61% and 46%, respectively. The distant metastasis-free survival (DMFS) for group A was 84% at 5 years and remained 84% at 8 years. The DMFS for group B was 60% at 5 years and 52% at 8 years. In multivariate analysis, initial local treatment (BCT vs. mastectomy without RT), pathologic T stage, locoregional recurrence site (local vs. regional), and DFI (≤4 years vs. ;gt; 4 years) were significant prognostic variables for both OS and DMFS. Conclusion Patients with breast cancer who developed ILRR after BCT as their initial local treatment have better clinical outcome compared with those who had mastectomy without RT.
AB - Introduction This study assessed the clinical outcome and prognostic factors in patients with breast cancer who presented with isolated locoregional recurrence (ILRR) as a first event. Materials and Methods Between 1970 and 2008, 2960 patients with pT1-2, N0-3, M0 primary invasive breast cancer had either breast-conserving therapy (BCT) using lumpectomy and radiation therapy (RT) (group A = 1849 patients) or mastectomy without RT (group B = 1111 patients). Out of groups A and B, 117 and 103 patients, respectively, developed ILRR as a first event. Those 220 patients served as the basis for this study. A multivariate analysis was performed to estimate the clinical outcome of both groups, taking into account clinically relevant variables for the primary tumor and ILRR. Results The median follow-up after ILRR was 83 months. The median disease-free interval (DFI) was 79 and 38 months for groups A and B, respectively. The overall survival (OS) for group A was 81% and 69% at 5 and 8 years, respectively. For group B, it was 61% and 46%, respectively. The distant metastasis-free survival (DMFS) for group A was 84% at 5 years and remained 84% at 8 years. The DMFS for group B was 60% at 5 years and 52% at 8 years. In multivariate analysis, initial local treatment (BCT vs. mastectomy without RT), pathologic T stage, locoregional recurrence site (local vs. regional), and DFI (≤4 years vs. ;gt; 4 years) were significant prognostic variables for both OS and DMFS. Conclusion Patients with breast cancer who developed ILRR after BCT as their initial local treatment have better clinical outcome compared with those who had mastectomy without RT.
KW - Breast cancer
KW - Isolated locoregional recurrence
KW - Local breast treatment
KW - Long-term clinical outcome
KW - Prognostic variables
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U2 - 10.1016/j.clbc.2013.12.007
DO - 10.1016/j.clbc.2013.12.007
M3 - Article
C2 - 24485702
AN - SCOPUS:84899922461
SN - 1526-8209
VL - 14
SP - 198
EP - 204
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
IS - 3
ER -