Clinical report - Probiotics and prebiotics in pediatrics

Dan W. Thomas, Frank R. Greer, Jatinder J.S. Bhatia, Steven A. Abrams, Stephen R. Daniels, Marcie Beth Schneider, Janet Silverstein, Nicolas Stettler, Leo A. Heitlinger, Robert D. Baker, David A. Gremse, Roberto Gugig, Jenifer R. Lightdale

Research output: Contribution to journalReview articlepeer-review

339 Scopus citations


This clinical report reviews the currently known health benefits of probiotic and prebiotic products, including those added to commercially available infant formula and other food products for use in children. Probiotics are supplements or foods that contain viable microorganisms that cause alterations of the microflora of the host. Use of probiotics has been shown to be modestly effective in randomized clinical trials (RCTs) in (1) treating acute viral gastroenteritis in healthy children; and (2) preventing antibiotic-associated diarrhea in healthy children. There is some evidence that probiotics prevent necrotizing enterocolitis in very low birth weight infants (birth weight between 1000 and 1500 g), but more studies are needed. The results of RCTs in which probiotics were used to treat childhood Helicobacter pylori gastritis, irritable bowel syndrome, chronic ulcerative colitis, and infantile colic, as well as in preventing childhood atopy, although encouraging, are preliminary and require further confirmation. Probiotics have not been proven to be beneficial in treating or preventing human cancers or in treating children with Crohn disease. There are also safety concerns with the use of probiotics in infants and children who are immunocompromised, chronically debilitated, or seriously ill with indwelling medical devices. Prebiotics are supplements or foods that contain a nondigestible food ingredient that selectively stimulates the favorable growth and/or activity of indigenous probiotic bacteria. Human milk contains substantial quantities of prebiotics. There is a paucity of RCTs examining prebiotics in children, although there may be some long-term benefit of prebiotics for the prevention of atopic eczema and common infections in healthy infants. Confirmatory well-designed clinical research studies are necessary.

Original languageEnglish (US)
Pages (from-to)1217-1231
Number of pages15
Issue number6
StatePublished - Dec 2010


  • Nutrition
  • Pediatrics
  • Prebiotics
  • Probiotics
  • Supplements

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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