Clinical utility of the Wechsler Memory Scale-Fourth Edition (WMS-IV) in predicting laterality of temporal lobe epilepsy among surgical candidates

Jason R. Soble, Katie E. Eichstaedt, Hena Waseem, Michelle L. Mattingly, Selim R. Benbadis, Ali M. Bozorg, Fernando L. Vale, Mike R. Schoenberg

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


This study evaluated the accuracy of the Wechsler Memory Scale-Fourth Edition (WMS-IV) in identifying functional cognitive deficits associated with seizure laterality in localization-related temporal lobe epilepsy (TLE) relative to a previously established measure, the Rey Auditory Verbal Learning Test (RAVLT). Emerging WMS-IV studies have highlighted psychometric improvements that may enhance its ability to identify lateralized memory deficits. Data from 57 patients with video-EEG-confirmed unilateral TLE who were administered the WMS-IV and RAVLT as part of a comprehensive presurgical neuropsychological evaluation for temporal resection were retrospectively reviewed. We examined the predictive accuracy of the WMS-IV not only in terms of verbal versus visual composite scores but also using individual subtests. A series of hierarchal logistic regression models were developed, including the RAVLT, WMS-IV delayed subtests (Logical Memory, Verbal Paired Associates, Designs, Visual Reproduction), and a WMS-IV verbal-visual memory difference score. Analyses showed that the RAVLT significantly predicted laterality with overall classification rates of 69.6% to 70.2%, whereas neither the individual WMS-IV subtests nor the verbal-visual memory difference score accounted for additional significant variance. Similar to previous versions of the WMS, findings cast doubt as to whether the WMS-IV offers significant incremental validity in discriminating seizure laterality in TLE beyond what can be obtained from the RAVLT.

Original languageEnglish (US)
Pages (from-to)232-237
Number of pages6
JournalEpilepsy and Behavior
StatePublished - Dec 1 2014
Externally publishedYes


  • Neuropsychological assessment
  • Presurgical evaluation
  • Rey Auditory Verbal Learning Test (RAVLT)
  • Temporal lobe epilepsy
  • Wechsler Memory Scale-Fourth Edition (WMS-IV)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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