@article{fa1d9cbcf646492c865546b45557fb09,
title = "Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia",
abstract = "In this multicenter study of 100 patients with cervical dystonia, we examined the immunogenicity of botulinum toxin type B (BTX-B) and correlated the clinical response with the presence of blocking antibodies (Abs) using a novel mouse protection assay. One-third of the patients who were negative for BTX-B Abs at baseline became positive for BTX-B Abs at last visit. Thus, the high antigenicity of BTX-B limits its long-term efficacy.",
author = "J. Jankovic and C. Hunter and Dolimbek, {B. Z.} and Dolimbek, {G. S.} and Adler, {C. H.} and A. Brashear and Comella, {C. L.} and M. Gordon and Riley, {D. E.} and K. Sethi and C. Singer and M. Stacy and D. Tarsy and Atassi, {M. Z.}",
note = "Funding Information: Dr. Atassi thanks the Welch Foundation for the award of the Robert A. Welch Chair of Chemistry. The authors thank Kevin Dat Vuong, MA, and Anthony Davidson for their help with data analysis. ",
year = "2006",
month = dec,
doi = "10.1212/01.wnl.0000249308.66959.43",
language = "English (US)",
volume = "67",
pages = "2233--2235",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "12",
}