Clomiphene blocks the effect of intravenous estradiol on the firing rate of rat nigral dopamine neurons

W. Vaughn McCall; E. H. Ellinwood; J. K. Nishita; T. H. Lee

Clomiphene blocks the effect of intravenous estradiol on the firing rate of rat nigral dopamine neurons

W. Vaughn McCall, E. H. Ellinwood, J. K. Nishita, T. H. Lee

Research output: Contribution to journal › Article › peer-review

Abstract

Intravenous 17-beta-estradiol (BETA) has a potent, stereospecific, and rapid effect on dopamine (DA) neuron firing rate in the substantia nigra compacta (SNC). Our data demonstrate that immediate intravenous pretreatment with the anti-estrogen clomiphene (CLOM) blocks the action of subsequent intravenous BETA administration. Our results provide further physiologic evidence for membrane-bound estradiol (E2) receptors within the rat brain.

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	60
Issue number	1
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Intravenous 17-beta-estradiol (BETA) has a potent, stereospecific, and rapid effect on dopamine (DA) neuron firing rate in the substantia nigra compacta (SNC). Our data demonstrate that immediate intravenous pretreatment with the anti-estrogen clomiphene (CLOM) blocks the action of subsequent intravenous BETA administration. Our results provide further physiologic evidence for membrane-bound estradiol (E2) receptors within the rat brain.",

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AU - Ellinwood, E. H.

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AU - Lee, T. H.

PY - 1988

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AB - Intravenous 17-beta-estradiol (BETA) has a potent, stereospecific, and rapid effect on dopamine (DA) neuron firing rate in the substantia nigra compacta (SNC). Our data demonstrate that immediate intravenous pretreatment with the anti-estrogen clomiphene (CLOM) blocks the action of subsequent intravenous BETA administration. Our results provide further physiologic evidence for membrane-bound estradiol (E2) receptors within the rat brain.

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ER -

Clomiphene blocks the effect of intravenous estradiol on the firing rate of rat nigral dopamine neurons

Abstract

ASJC Scopus subject areas

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