Abstract
Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned. This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes from human chromosome 1p22 which are associated with a constitutional chromosome translocation from a patient with stage 4S neuroblastoma, we have identified the human homologue of the Gfi gene and defined a 50 Kb map position within a well characterised YAC contig from the region. The full length cDNA sequence is 81% homologous with the rodent counterparts and, at the protein level, is even more highly conserved.
Original language | English (US) |
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Pages (from-to) | 1003-1005 |
Number of pages | 3 |
Journal | Oncogene |
Volume | 14 |
Issue number | 8 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
Keywords
- CDNA sequence
- Chromosome 1p22
- Human Gfi gene
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research