Clozapine for self-injurious behavior in individuals with borderline personality disorder

Theodore Zarzar, Joseph McEvoy

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Prior reports suggest that clozapine can markedly reduce aggression and self-injurious behavior in patients with borderline personality disorder (BPD). We present a series of four patients with BPD and persistent self-injurious behavior treated with clozapine at a state psychiatric hospital. After treatment with clozapine these patients ceased self-injurious behaviors and aggression, and no longer required intensive levels of observation or restrictive procedures. All were successfully discharged from the hospital soon after initiation of clozapine. Clozapine appears to be efficacious in the management of chronic suicidality, self-injurious behaviors and aggression in patients with severe BPD.

Original languageEnglish (US)
Pages (from-to)272-274
Number of pages3
JournalTherapeutic Advances in Psychopharmacology
Issue number5
StatePublished - Oct 2013
Externally publishedYes


  • Borderline personality disorder
  • aggression
  • clozapine
  • suicide

ASJC Scopus subject areas

  • Psychology (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)


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