Clustered DNA damages as dosemeters for ionising radiation exposure and biological responses

B. M. Sutherland; P. V. Bennett; M. Saparbaev; J. C. Sutherland; J. Laval; R. J. Preston

Clustered DNA damages as dosemeters for ionising radiation exposure and biological responses

B. M. Sutherland, P. V. Bennett, M. Saparbaev, J. C. Sutherland, J. Laval, R. J. Preston

Research output: Contribution to journal › Article › peer-review

Abstract

Clustered DNA damages-two or more lesions (oxidised bases, abasic sites, or strand breaks) within a few DNA helical turns on opposing strands - are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance. Since the total of clustered damages produced by ionising radiation is at about 3 to 4 times higher levels than double-strand breaks and are apparently absent in unirradiated cells, levels of clustered damages present immediately after radiation exposure could serve as sensitive dosemeters of radiation exposure. Since some cluster may not be repairable and may accumulate in cells, they might also be useful as integrating dosemeters of biological effects of radiation damage.

Original language	English (US)
Pages (from-to)	33-38
Number of pages	6
Journal	Radiation Protection Dosimetry
Volume	97
Issue number	1
State	Published - Dec 10 2001
Externally published	Yes

ASJC Scopus subject areas

Radiation
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Clustered DNA damages-two or more lesions (oxidised bases, abasic sites, or strand breaks) within a few DNA helical turns on opposing strands - are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance. Since the total of clustered damages produced by ionising radiation is at about 3 to 4 times higher levels than double-strand breaks and are apparently absent in unirradiated cells, levels of clustered damages present immediately after radiation exposure could serve as sensitive dosemeters of radiation exposure. Since some cluster may not be repairable and may accumulate in cells, they might also be useful as integrating dosemeters of biological effects of radiation damage.",

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AU - Sutherland, B. M.

AU - Bennett, P. V.

AU - Saparbaev, M.

AU - Sutherland, J. C.

AU - Laval, J.

AU - Preston, R. J.

PY - 2001/12/10

Y1 - 2001/12/10

N2 - Clustered DNA damages-two or more lesions (oxidised bases, abasic sites, or strand breaks) within a few DNA helical turns on opposing strands - are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance. Since the total of clustered damages produced by ionising radiation is at about 3 to 4 times higher levels than double-strand breaks and are apparently absent in unirradiated cells, levels of clustered damages present immediately after radiation exposure could serve as sensitive dosemeters of radiation exposure. Since some cluster may not be repairable and may accumulate in cells, they might also be useful as integrating dosemeters of biological effects of radiation damage.

AB - Clustered DNA damages-two or more lesions (oxidised bases, abasic sites, or strand breaks) within a few DNA helical turns on opposing strands - are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance. Since the total of clustered damages produced by ionising radiation is at about 3 to 4 times higher levels than double-strand breaks and are apparently absent in unirradiated cells, levels of clustered damages present immediately after radiation exposure could serve as sensitive dosemeters of radiation exposure. Since some cluster may not be repairable and may accumulate in cells, they might also be useful as integrating dosemeters of biological effects of radiation damage.

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Clustered DNA damages as dosemeters for ionising radiation exposure and biological responses

Abstract

ASJC Scopus subject areas

UN SDGs

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