Cognitive Processing among Mothers of Children Undergoing Bone Marrow/Stem Cell Transplantation

Katherine N. DuHamel, Sharon Manne, Nancy Nereo, Jamie Ostroff, Richard Martini, Susan Parsons, Sharon Williams, Laura Mee, Sandra Griffin Bishop Sexson, Lisa Wu, Gary Winkel, Farid Boulad, William H. Redd

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Objective: This study investigated the role of cognitive processing in maternal adjustment to a life-threatening pediatric medical procedure (bone marrow/stem cell transplantation: BMT/SCT). Methods: Ninety-one mothers participated in structured interviews about their fears, intrusions, avoidance, and distress regarding their child's BMT/SCT at two time points: during their child's hospitalization and during his/her recovery. Structural equation modeling was used to determine the role of fears, intrusions, and avoidance in mothers' distress. Results: Mothers' fears played a primary role in their adjustment to their child's transplantation. Intrusions mediated the relations of fears with distress at both time points. Mothers' avoidance of thoughts, feelings, and reminders of their child's illness during the child's transplantation was associated with their distress three months later. The child's risk for an unsuccessful transplantation outcome was not associated with mothers' fears or distress during the child's hospitalization, but was associated with mothers' distress during the child's posthospital course of recovery. Conclusions: The results of this study indicate the critical role of mothers' fears, intrusions, avoidance, and the child's transplant risk in maternal distress and have treatment implications for reducing maternal distress during pediatric transplantation.

Original languageEnglish (US)
Pages (from-to)92-103
Number of pages12
JournalPsychosomatic Medicine
Issue number1
StatePublished - Jan 2004
Externally publishedYes


  • Bone marrow and stem cell transplantation
  • Cancer
  • Cognitive processing
  • Mothers
  • Pediatric

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


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