Collision metastasis of prostatic adenocarcinoma and urothelial carcinoma of the bladder

David P. Sellman, Leslie Peard, Greg Simpson, Katrina Lancaster, Sravan Kumar Kavuri, Martha Kennedy Terris, Rabii Hussein Madi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The incidence of concomitant prostate adenocarcinoma found in patients with muscle-invasive bladder carcinoma is not uncommon, reaching up to 21%-28%. However, the presence of collision metastasis involving prostate cancer and bladder cancer within the same lymph node is exceedingly rare, with only 5 cases reported to date in the literature. We report a case of collision metastasis of prostate adenocarcinoma and urothelial carcinoma of the bladder in a 73-year-old man who underwent cystoprostatectomy with bilateral pelvic lymph node dissection for high-grade muscle-invasive urothelial carcinoma. Final pathology revealed a pT3aN2 high-grade urothelial carcinoma and pT3N1 Gleason 4 + 4 = 8 adenocarcinoma of the prostate with 12/40 pelvic lymph nodes positive for urothelial carcinoma. One node was positive for both urothelial carcinoma and prostate adenocarcinoma, confirmed by positive staining by p40 and prostate specific antigen(PSA), respectively. Immunohistochemistry is the sole method of confirming collision metastasis of two primary cancers. In this case, we describe immunohistochemical markers for urothelial carcinoma and prostate adenocarcinoma and their clinical implications. One month postoperatively, our patient began adjuvant leuprolide therapy and cycle 1 of gemcitabine and cisplatin chemotherapy, which he is tolerating well.

Original languageEnglish (US)
Pages (from-to)342-344
Number of pages3
JournalUrology Annals
Issue number3
StatePublished - Jul 1 2018


  • Bladder cancer
  • collision metastasis
  • immunohistochemistry
  • prostate cancer

ASJC Scopus subject areas

  • Urology


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