Colorectal cancer: New pharmacologic strategies for prevention and treatment

P. M. Dainer, C. R. DiPiro, C. S. Richards

Research output: Contribution to journalReview articlepeer-review


Despite technological advances allowing for earlier detection of colorectal cancer and more effective treatment options, approximately 57,000 people will die from colorectal cancer in 1993. Prospective studies have shown positive correlations between high-fat, low-fiber diets and colorectal adenomas and carcinomas. Dietary intervention appears to have potential as a preventive measure; however, cultural and behavioral eating habits may prove difficult to overcome. Prostaglandin and ornithine decarboxylase inhibitors show promise as chemopreventive agents. Leucovorin, levamisole, interferon, and N-(phosphonacetyl)-1-aspartic acid (PALA) modulation of 5-fluorouracil (5-FU) continues to be studied for the treatment of metastatic disease. Adjuvant therapy represents the area of greatest gain in the medical treatment of colon cancer.

Original languageEnglish (US)
Pages (from-to)354-360+363
JournalHospital Formulary
Issue number4
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pharmaceutical Science


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