Abstract
Patients with T-cell large granular lymphocyte (T-LGL) leukaemia and autoimmune lymphoproliferative syndrome (ALPS) share many features, including autoimmunity and an expansion of (cytotoxic) T cells, which in ALPS patients express an unusual (B220) isoform of CD45, corresponding to an altered O-glycosylation profile. Here we showed that T-LGL leukaemia cells also expressed this B220 isoform. We hypothesize that B220+ T cells constitute proliferating T cells that have become competent to undergo apoptosis, but that constitutive (ALPS) or functional (T-LGL) defects prevent this process. Altered O-glycosylation of the extracellular domains of CD45 may have consequences for this tyrosine phosphatase as a regulator of cell proliferation and survival.
Original language | English (US) |
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Pages (from-to) | 93-96 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 120 |
Issue number | 1 |
DOIs | |
State | Published - 2003 |
Externally published | Yes |
Keywords
- Apoptosis
- Autoimmune lymphoproliferative syndrome
- CD45 isoforms
- Glycosylation
- T-LGL leukaemia
ASJC Scopus subject areas
- Hematology