Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG trial

Ram Kalpatthi; Bruce Thompson; Ming Lu; Winfred C. Wang; Niren Patel; Abdullah Kutlar; Thomas Howard; Lori Luchtman-Jones; Scott T. Miller

doi:10.1016/j.clinbiochem.2012.10.032

Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG trial

Ram Kalpatthi, Bruce Thompson, Ming Lu, Winfred C. Wang, Niren Patel, Abdullah Kutlar, Thomas Howard, Lori Luchtman-Jones, Scott T. Miller

Pulmonary Disease

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10 Scopus citations

Abstract

Objectives: To investigate the concordance of blood count indices measured locally and at a central laboratory. Design and methods: In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and at a central laboratory was investigated. Results: Local laboratory measurements of neutrophil and monocyte counts were significantly higher (44% and 37%, respectively) compared to the central measurements (p<0.0001), and mean corpuscular volume (MCV) was higher centrally. Conclusion: Overnight shipping with processing delay causes spurious reductions in absolute neutrophil count (ANC) and absolute monocyte count (AMC) that may result in incorrect monitoring decisions in multicenter clinical trials.

Original language	English (US)
Pages (from-to)	278-281
Number of pages	4
Journal	Clinical Biochemistry
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.clinbiochem.2012.10.032
State	Published - Feb 2013

Keywords

Clinical trial
Complete blood count
Neutrophil
Shipping
Transportation

ASJC Scopus subject areas

Clinical Biochemistry

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10.1016/j.clinbiochem.2012.10.032

Cite this

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abstract = "Objectives: To investigate the concordance of blood count indices measured locally and at a central laboratory. Design and methods: In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and at a central laboratory was investigated. Results: Local laboratory measurements of neutrophil and monocyte counts were significantly higher (44% and 37%, respectively) compared to the central measurements (p<0.0001), and mean corpuscular volume (MCV) was higher centrally. Conclusion: Overnight shipping with processing delay causes spurious reductions in absolute neutrophil count (ANC) and absolute monocyte count (AMC) that may result in incorrect monitoring decisions in multicenter clinical trials.",

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T2 - Data from the BABY HUG trial

AU - Kalpatthi, Ram

AU - Thompson, Bruce

AU - Lu, Ming

AU - Wang, Winfred C.

AU - Patel, Niren

AU - Kutlar, Abdullah

AU - Howard, Thomas

AU - Luchtman-Jones, Lori

AU - Miller, Scott T.

PY - 2013/2

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AB - Objectives: To investigate the concordance of blood count indices measured locally and at a central laboratory. Design and methods: In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and at a central laboratory was investigated. Results: Local laboratory measurements of neutrophil and monocyte counts were significantly higher (44% and 37%, respectively) compared to the central measurements (p<0.0001), and mean corpuscular volume (MCV) was higher centrally. Conclusion: Overnight shipping with processing delay causes spurious reductions in absolute neutrophil count (ANC) and absolute monocyte count (AMC) that may result in incorrect monitoring decisions in multicenter clinical trials.

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Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG trial

Abstract

Keywords

ASJC Scopus subject areas

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