Comparison of the QTDT analysis for IgE in the CSGA data set

G. P. Page; M. A. Wilcox; J. Occhiuto; S. Adak; D. Neuberg; R. Bajorunaite; V. George

doi:10.1002/gepi.2001.21.s1.s312

Comparison of the QTDT analysis for IgE in the CSGA data set

G. P. Page, M. A. Wilcox, J. Occhiuto, S. Adak, D. Neuberg, R. Bajorunaite, V. George

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log₁₀IgE in the Collaborative Study on the Genetics of Asthma data set. Only moderate agreement was found between the tests. The results of the QTDT analyses were only slightly affected by the use of gender and age as covariates. Results from analysis of IgE and log₁₀IgE were inconsistent. Our conclusion is that there is only modest agreement among the QTDT methods examined, covariates should be used even if they have a small effect, and that data should be normalized before analysis.

Original language	English (US)
Pages (from-to)	S312-S316
Journal	Genetic Epidemiology
Volume	21
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/gepi.2001.21.s1.s312
State	Published - 2001
Externally published	Yes

Keywords

Chromosome 5
IgE
QTDT

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

Access to Document

10.1002/gepi.2001.21.s1.s312

Cite this

@article{03aa8b5a13d848fa9e0e39e707b099b4,

title = "Comparison of the QTDT analysis for IgE in the CSGA data set",

abstract = "Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log10IgE in the Collaborative Study on the Genetics of Asthma data set. Only moderate agreement was found between the tests. The results of the QTDT analyses were only slightly affected by the use of gender and age as covariates. Results from analysis of IgE and log10IgE were inconsistent. Our conclusion is that there is only modest agreement among the QTDT methods examined, covariates should be used even if they have a small effect, and that data should be normalized before analysis.",

keywords = "Chromosome 5, IgE, QTDT",

author = "Page, {G. P.} and Wilcox, {M. A.} and J. Occhiuto and S. Adak and D. Neuberg and R. Bajorunaite and V. George",

year = "2001",

doi = "10.1002/gepi.2001.21.s1.s312",

language = "English (US)",

volume = "21",

pages = "S312--S316",

journal = "Genetic Epidemiology",

issn = "0741-0395",

publisher = "Wiley-Liss Inc.",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Comparison of the QTDT analysis for IgE in the CSGA data set

AU - Page, G. P.

AU - Wilcox, M. A.

AU - Occhiuto, J.

AU - Adak, S.

AU - Neuberg, D.

AU - Bajorunaite, R.

AU - George, V.

PY - 2001

Y1 - 2001

N2 - Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log10IgE in the Collaborative Study on the Genetics of Asthma data set. Only moderate agreement was found between the tests. The results of the QTDT analyses were only slightly affected by the use of gender and age as covariates. Results from analysis of IgE and log10IgE were inconsistent. Our conclusion is that there is only modest agreement among the QTDT methods examined, covariates should be used even if they have a small effect, and that data should be normalized before analysis.

AB - Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log10IgE in the Collaborative Study on the Genetics of Asthma data set. Only moderate agreement was found between the tests. The results of the QTDT analyses were only slightly affected by the use of gender and age as covariates. Results from analysis of IgE and log10IgE were inconsistent. Our conclusion is that there is only modest agreement among the QTDT methods examined, covariates should be used even if they have a small effect, and that data should be normalized before analysis.

KW - Chromosome 5

KW - IgE

KW - QTDT

UR - http://www.scopus.com/inward/record.url?scp=0034793129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034793129&partnerID=8YFLogxK

U2 - 10.1002/gepi.2001.21.s1.s312

DO - 10.1002/gepi.2001.21.s1.s312

M3 - Article

C2 - 11793690

AN - SCOPUS:0034793129

SN - 0741-0395

VL - 21

SP - S312-S316

JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - SUPPL. 1

ER -

Comparison of the QTDT analysis for IgE in the CSGA data set

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this