@article{e169a5834d3d49828764b172c602a72d,
title = "Complex role of NK cells in regulation of oncolytic virus–bortezomib therapy",
abstract = "In the present work, we investigated the role of natural killer (NK) cells in combination therapy with oncolytic virus (OV) and bortezomib, a proteasome inhibitor. NK cells display rapid and potent immunity to metastatic and hematological cancers, and they overcome immunosuppressive effects of tumor microenvironment. We developed a mathematical model to address the question of how the density of NK cells affects the growth of the tumor. We found that the antitumor efficacy increases when the endogenous NKs are depleted and also when exogenous NK cells are injected into the tumor. These predictions were validated by our in vivo and in vitro experiments.",
keywords = "Bortezomib, NK cells, Oncolytic virus, Partial differential equations models, Tumor microenvironment",
author = "Yangjin Kim and Yoo, {Ji Young} and Lee, {Tae Jin} and Joseph Liu and Jianhua Yu and Caligiuri, {Michael A.} and Balveen Kaur and Avner Friedman",
note = "Funding Information: ACKNOWLEDGMENTS. This work was supported in part by a National Science Foundation award (Y.K. and A.F.); National Institutes of Health Grants CA150153, CA163205, NS045758, and NS064607 (to B.K.); the Basic Science Research Program through the National Research Foundation of Korea funded by Ministry of Education Grant NRF-2015R1D1A1A01058702 (to Y.K.); and Konkuk University{\textquoteright}s research support program for its faculty on sabbatical leave in 2017 (Y.K.). Funding Information: This work was supported in part by a National Science Foundation award (Y.K. and A.F.); National Institutes of Health Grants CA150153, CA163205, NS045758, and NS064607 (to B.K.); the Basic Science Research Program through the National Research Foundation of Korea funded by Ministry of Education Grant NRF-2015R1D1A1A01058702 (to Y.K.); and Konkuk University{\textquoteright}s research support program for its faculty on sabbatical leave in 2017 (Y.K.). Publisher Copyright: {\textcopyright} 2018 National Academy of Sciences. All rights reserved.",
year = "2018",
month = may,
day = "8",
doi = "10.1073/pnas.1715295115",
language = "English (US)",
volume = "115",
pages = "4927--4932",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "19",
}
