COMT158 Polymorphism and Hostility

Jan Volavka, James L. Kennedy, Xingqun Ni, Pal Czobor, Karen Nolan, Brian Sheitman, Jean Pierre Lindenmayer, Leslie Citrome, Joseph Patrick McEvoy, Jeffrey A. Lieberman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The main study was designed primarily to compare the clinical effects of four antipsychotics in 157 patients with schizophrenia or schizoaffective disorder. The secondary genetic study, reported here, is based on a subset of 60 patients who consented to genotyping assays. Based on previous work with the catechol-O-methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met-Met homozygotes would be more hostile than the heterozygotes and the Val-Val homozygotes. Hostility ratings at baseline were used to test this hypothesis. The Met-Met homozygotes (N = 7) were found to have significantly higher levels of hostility than the other patients (N = 53). The hypothesis was thus supported. The finding should be replicated in a larger sample.

Original languageEnglish (US)
Pages (from-to)28-29
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume127 B
Issue number1
StatePublished - May 15 2004
Externally publishedYes


  • Aggression
  • Catechol-O-methyltransferase
  • Schizoaffective disorder
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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